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Plpp4 phospholipid phosphatase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309014, updated on 2-Nov-2024

Summary

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Official Symbol
Plpp4provided by RGD
Official Full Name
phospholipid phosphatase 4provided by RGD
Primary source
RGD:1306289
See related
EnsemblRapid:ENSRNOG00000020424 AllianceGenome:RGD:1306289
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ppapdc1a; RGD1306289
Summary
Predicted to enable diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and regulation of calcium ion import. Predicted to act upstream of or within blastocyst hatching. Predicted to be active in membrane. Orthologous to human PLPP4 (phospholipid phosphatase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 36.0), Lung (RPKM 24.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plpp4 in Genome Data Viewer
Location:
1q37
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (193260181..193389659)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (183829794..183959319)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (202432366..202560628)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349652 Neighboring gene uncharacterized LOC134484913 Neighboring gene uncharacterized LOC134485180 Neighboring gene presenilin associated, rhomboid-like, pseudogene 1 Neighboring gene uncharacterized LOC120098013

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca(2+)-permeable Cationic Channel in lung carcinoma cells. Zhang X, et al. Mol Cancer, 2017 Aug 29. PMID 28851360, Free PMC Article
  2. Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Dahl E, et al. Clin Cancer Res, 2006 Jul 1. PMID 16818692
  3. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. Takeuchi M, et al. Gene, 2007 Sep 15. PMID 17590538
  4. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables diacylglycerol diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid phosphatase 4
Names
phosphatidate phosphatase PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
NP_001178560.1
XP_017444709.1
XP_038934456.1
XP_038934461.1
XP_038934467.1
XP_063119499.1
XP_063119505.1
XP_063119508.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191631.1 → NP_001178560.1  phospholipid phosphatase 4

    See identical proteins and their annotated locations for NP_001178560.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1LZ94
    Related
    ENSRNOP00000027681.6, ENSRNOT00000027681.8
    Conserved Domains (1) summary
    cd03390
    Location:37 → 225
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    193260181..193389659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078528.2 → XP_038934456.1  phospholipid phosphatase 4 isoform X2

    Conserved Domains (1) summary
    cd03390
    Location:37 → 206
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  2. XM_039078539.2 → XP_038934467.1  phospholipid phosphatase 4 isoform X5

    Conserved Domains (1) summary
    cl00474
    Location:37 → 144
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  3. XM_063263429.1 → XP_063119499.1  phospholipid phosphatase 4 isoform X1

    Related
    ENSRNOP00000099087.1, ENSRNOT00000145246.1

  4. XM_039078533.2 → XP_038934461.1  phospholipid phosphatase 4 isoform X4

    Conserved Domains (1) summary
    cd03390
    Location:37 → 168
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  5. XM_017589220.2 → XP_017444709.1  phospholipid phosphatase 4 isoform X6

    Conserved Domains (1) summary
    cl00474
    Location:37 → 162
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  6. XM_063263435.1 → XP_063119505.1  phospholipid phosphatase 4 isoform X3

  7. XM_063263438.1 → XP_063119508.1  phospholipid phosphatase 4 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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