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Tacc2 transforming, acidic coiled-coil containing protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309025, updated on 18-Sep-2024

Summary

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Official Symbol
Tacc2provided by RGD
Official Full Name
transforming, acidic coiled-coil containing protein 2provided by RGD
Primary source
RGD:1303004
See related
EnsemblRapid:ENSRNOG00000020457 AllianceGenome:RGD:1303004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Muscle (RPKM 319.1), Heart (RPKM 196.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tacc2 in Genome Data Viewer
Location:
1q37
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194546428..194758152)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185139223..185327881)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201140264..201329612)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 1700022C21 Neighboring gene uncharacterized LOC134483930 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene transfer RNA proline (anticodon AGG) 25 Neighboring gene uncharacterized LOC103691241 Neighboring gene uncharacterized LOC134483936 Neighboring gene BTB domain containing 16 Neighboring gene pleckstrin homology domain containing A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression pattern of an evolutionarily conserved splice variant in the rat Tacc2 gene. Padhi BK, et al. Genesis, 2014 May. PMID 24700488
  2. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Xie Z, et al. Neuron, 2007 Oct 4. PMID 17920017, Free PMC Article
  3. Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. Still IH, et al. BMC Evol Biol, 2004 Jun 18. PMID 15207008, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within astral microtubule organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within interkinetic nuclear migration ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transforming acidic coiled-coil-containing protein 2
Names
transforming acidic coiled coil 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004415.3 → NP_001004415.1  transforming acidic coiled-coil-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), also called the long form, represents the longer transcript.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZXK3
    Related
    ENSRNOP00000051820.4, ENSRNOT00000054937.7
    Conserved Domains (3) summary
    pfam05010
    Location:2628 → 2828
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2739 → 2827
    FadA; Adhesion protein FadA
    cl23765
    Location:2647 → 2764
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_001004418.3 → NP_001004418.1  transforming acidic coiled-coil-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also called the short form, lacks an in-frame exon in the coding region, compared to variant 1. Variant 2 encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D4A858
    Related
    ENSRNOP00000042296.3, ENSRNOT00000047161.6
    Conserved Domains (3) summary
    pfam05010
    Location:923 → 1123
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:1034 → 1122
    FadA; Adhesion protein FadA
    cl23765
    Location:942 → 1044
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. NM_001415936.1 → NP_001402865.1  transforming acidic coiled-coil-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D4A858, X4YHC6

  4. NM_001415937.1 → NP_001402866.1  transforming acidic coiled-coil-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5Y8E6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    194546428..194758152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263499.1 → XP_063119569.1  transforming acidic coiled-coil-containing protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A0G2K598

  2. XM_063263527.1 → XP_063119597.1  transforming acidic coiled-coil-containing protein 2 isoform X19

    UniProtKB/TrEMBL
    D4A858

  3. XM_063263507.1 → XP_063119577.1  transforming acidic coiled-coil-containing protein 2 isoform X15

    UniProtKB/TrEMBL
    A0A0G2K598

  4. XM_063263532.1 → XP_063119602.1  transforming acidic coiled-coil-containing protein 2 isoform X20

    UniProtKB/TrEMBL
    D4A858

  5. XM_063263562.1 → XP_063119632.1  transforming acidic coiled-coil-containing protein 2 isoform X27

    UniProtKB/TrEMBL
    D4A858

  6. XM_063263617.1 → XP_063119687.1  transforming acidic coiled-coil-containing protein 2 isoform X42

    UniProtKB/TrEMBL
    D3ZXK3

  7. XM_063263519.1 → XP_063119589.1  transforming acidic coiled-coil-containing protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A0G2K598

  8. XM_063263502.1 → XP_063119572.1  transforming acidic coiled-coil-containing protein 2 isoform X13

    UniProtKB/TrEMBL
    A0A0G2K598

  9. XM_063263469.1 → XP_063119539.1  transforming acidic coiled-coil-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K598

  10. XM_063263487.1 → XP_063119557.1  transforming acidic coiled-coil-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6AK68

  11. XM_063263471.1 → XP_063119541.1  transforming acidic coiled-coil-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    D3ZXK3

  12. XM_063263480.1 → XP_063119550.1  transforming acidic coiled-coil-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    D3ZXK3

  13. XM_063263505.1 → XP_063119575.1  transforming acidic coiled-coil-containing protein 2 isoform X14

    UniProtKB/TrEMBL
    A0A8I6AK68

  14. XM_063263464.1 → XP_063119534.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K598
    Related
    ENSRNOP00000073346.3, ENSRNOT00000077908.3

  15. XM_039078550.2 → XP_038934478.2  transforming acidic coiled-coil-containing protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6AK68
    Related
    ENSRNOP00000095666.2, ENSRNOT00000096415.2

  16. XM_063263476.1 → XP_063119546.1  transforming acidic coiled-coil-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    D3ZXK3

  17. XM_063263484.1 → XP_063119554.1  transforming acidic coiled-coil-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    D3ZXK3

  18. XM_063263513.1 → XP_063119583.1  transforming acidic coiled-coil-containing protein 2 isoform X16

    UniProtKB/TrEMBL
    A0A8I6AK68

  19. XM_063263466.1 → XP_063119536.1  transforming acidic coiled-coil-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K598

  20. XM_063263488.1 → XP_063119558.1  transforming acidic coiled-coil-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    D3ZXK3

  21. XM_063263516.1 → XP_063119586.1  transforming acidic coiled-coil-containing protein 2 isoform X17

    UniProtKB/TrEMBL
    A0A8I6AK68

  22. XM_063263474.1 → XP_063119544.1  transforming acidic coiled-coil-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K598

  23. XM_063263613.1 → XP_063119683.1  transforming acidic coiled-coil-containing protein 2 isoform X41

    UniProtKB/TrEMBL
    A0A8I5Y8E6

  24. XM_063263565.1 → XP_063119635.1  transforming acidic coiled-coil-containing protein 2 isoform X28

    UniProtKB/TrEMBL
    A0A8I5Y8E6

  25. XM_063263592.1 → XP_063119662.1  transforming acidic coiled-coil-containing protein 2 isoform X35

    UniProtKB/TrEMBL
    A0A8I5Y8E6

  26. XM_063263607.1 → XP_063119677.1  transforming acidic coiled-coil-containing protein 2 isoform X39

    UniProtKB/TrEMBL
    A0A8I5XWM5, A0A8I5Y8E6
    Related
    ENSRNOP00000078070.1, ENSRNOT00000100208.2

  27. XM_063263611.1 → XP_063119681.1  transforming acidic coiled-coil-containing protein 2 isoform X40

    UniProtKB/TrEMBL
    A0A8I5Y8E6, A0A8I6AEP2
    Related
    ENSRNOP00000092850.1, ENSRNOT00000103884.2

  28. XM_063263612.1 → XP_063119682.1  transforming acidic coiled-coil-containing protein 2 isoform X39

    UniProtKB/TrEMBL
    A0A8I5XWM5, A0A8I5Y8E6

  29. XM_063263555.1 → XP_063119625.1  transforming acidic coiled-coil-containing protein 2 isoform X24

    UniProtKB/TrEMBL
    D4A858

  30. XM_063263543.1 → XP_063119613.1  transforming acidic coiled-coil-containing protein 2 isoform X22

    UniProtKB/TrEMBL
    D4A858

  31. XM_017589222.3 → XP_017444711.1  transforming acidic coiled-coil-containing protein 2 isoform X25

    UniProtKB/TrEMBL
    A0A0G2JTE3, D4A858
    Related
    ENSRNOP00000068677.2, ENSRNOT00000090143.3

  32. XM_017589223.3 → XP_017444712.1  transforming acidic coiled-coil-containing protein 2 isoform X30

    UniProtKB/TrEMBL
    D4A858

  33. XM_063263589.1 → XP_063119659.1  transforming acidic coiled-coil-containing protein 2 isoform X33

    UniProtKB/TrEMBL
    D4A858

  34. XM_063263606.1 → XP_063119676.1  transforming acidic coiled-coil-containing protein 2 isoform X38

    UniProtKB/TrEMBL
    A6IA38

  35. XM_063263560.1 → XP_063119630.1  transforming acidic coiled-coil-containing protein 2 isoform X26

    UniProtKB/TrEMBL
    D4A858

  36. XM_063263550.1 → XP_063119620.1  transforming acidic coiled-coil-containing protein 2 isoform X23

    UniProtKB/TrEMBL
    D4A858

  37. XM_008759883.4 → XP_008758105.1  transforming acidic coiled-coil-containing protein 2 isoform X32

    UniProtKB/TrEMBL
    D4A858
    Related
    ENSRNOP00000077927.2, ENSRNOT00000119746.2
    Conserved Domains (3) summary
    pfam05010
    Location:785 → 985
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:896 → 984
    FadA; Adhesion protein FadA
    cl11495
    Location:788 → 912
    IncFII_repA; IncFII RepA protein family

  38. XM_063263591.1 → XP_063119661.1  transforming acidic coiled-coil-containing protein 2 isoform X34

    UniProtKB/TrEMBL
    A6IA38

  39. XM_039078566.2 → XP_038934494.1  transforming acidic coiled-coil-containing protein 2 isoform X37

    UniProtKB/TrEMBL
    A6IA38
    Conserved Domains (2) summary
    PRK13335
    Location:181 → 292
    PRK13335; superantigen-like protein SSL3; Reviewed
    pfam05010
    Location:738 → 938
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  40. XM_063263597.1 → XP_063119667.1  transforming acidic coiled-coil-containing protein 2 isoform X36

    UniProtKB/TrEMBL
    D4A858

  41. XM_063263569.1 → XP_063119639.1  transforming acidic coiled-coil-containing protein 2 isoform X29

    UniProtKB/TrEMBL
    D4A858

  42. XM_063263537.1 → XP_063119607.1  transforming acidic coiled-coil-containing protein 2 isoform X21

    UniProtKB/TrEMBL
    D4A858

  43. XM_063263577.1 → XP_063119647.1  transforming acidic coiled-coil-containing protein 2 isoform X31

    UniProtKB/TrEMBL
    D4A858
Nucleotide Protein Strain
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