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Relch RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 309053, updated on 2-Nov-2024

Summary

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Official Symbol
Relchprovided by RGD
Official Full Name
RAB11 binding and LisH domain, coiled-coil and HEAT repeat containingprovided by RGD
Primary source
RGD:1307235
See related
EnsemblRapid:ENSRNOG00000015508 AllianceGenome:RGD:1307235
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307235
Summary
Predicted to be involved in intracellular cholesterol transport. Predicted to be active in recycling endosome and trans-Golgi network. Orthologous to human RELCH (RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 175.3), Thymus (RPKM 171.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Relch in Genome Data Viewer
Location:
13p11
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (22321495..22417371)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (21806972..21902807)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (25656983..25752792)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class N Neighboring gene transfer RNA histidin (anticodon AUG) 1 Neighboring gene TNF receptor superfamily member 11A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. Sobajima T, et al. J Cell Biol, 2018 May 7. PMID 29514919, Free PMC Article
  2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAB11-binding protein RELCH

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134546.1 → NP_001128018.1  RAB11-binding protein RELCH

    See identical proteins and their annotated locations for NP_001128018.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474000
    UniProtKB/TrEMBL
    A0A8I6AUX6, A6JST7, D3ZJ01
    Related
    ENSRNOP00000020892.4, ENSRNOT00000020892.6
    Conserved Domains (1) summary
    sd00044
    Location:521 → 553
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    22321495..22417371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090853.2 → XP_038946781.1  RAB11-binding protein RELCH isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRA1, A0A8I6AUX6
    Related
    ENSRNOP00000080664.1, ENSRNOT00000107072.2
    Conserved Domains (1) summary
    sd00044
    Location:650 → 679
    HEAT; HEAT repeat [structural motif]

  2. XM_039090854.2 → XP_038946782.1  RAB11-binding protein RELCH isoform X2

    UniProtKB/TrEMBL
    A0A8I6AUX6
    Conserved Domains (1) summary
    sd00044
    Location:650 → 679
    HEAT; HEAT repeat [structural motif]

  3. XM_039090855.2 → XP_038946783.1  RAB11-binding protein RELCH isoform X3

    UniProtKB/TrEMBL
    A0A8I6AUX6
    Conserved Domains (1) summary
    sd00044
    Location:650 → 679
    HEAT; HEAT repeat [structural motif]

  4. XM_039090856.2 → XP_038946784.1  RAB11-binding protein RELCH isoform X4

    UniProtKB/TrEMBL
    A0A8I6AUX6
    Conserved Domains (1) summary
    sd00044
    Location:650 → 679
    HEAT; HEAT repeat [structural motif]

  5. XM_039090857.2 → XP_038946785.1  RAB11-binding protein RELCH isoform X5

    UniProtKB/TrEMBL
    A0A8I6ARP7, A0A8I6AUX6
    Related
    ENSRNOP00000096002.1, ENSRNOT00000113641.2
    Conserved Domains (1) summary
    sd00044
    Location:521 → 553
    HEAT; HEAT repeat [structural motif]

  6. XM_063272420.1 → XP_063128490.1  RAB11-binding protein RELCH isoform X6

  7. XM_039090859.2 → XP_038946787.1  RAB11-binding protein RELCH isoform X7

    UniProtKB/TrEMBL
    A0A8I6AUX6
    Conserved Domains (1) summary
    sd00044
    Location:521 → 553
    HEAT; HEAT repeat [structural motif]

  8. XM_039090860.2 → XP_038946788.1  RAB11-binding protein RELCH isoform X8

    UniProtKB/TrEMBL
    A0A8I6AUX6
    Related
    ENSRNOP00000090311.2, ENSRNOT00000093768.2
    Conserved Domains (1) summary
    sd00044
    Location:626 → 655
    HEAT; HEAT repeat [structural motif]

  9. XM_039090861.2 → XP_038946789.1  RAB11-binding protein RELCH isoform X9

    UniProtKB/TrEMBL
    A0A8I6AUX6, A0A8I6GIS7
    Conserved Domains (1) summary
    sd00044
    Location:497 → 529
    HEAT; HEAT repeat [structural motif]

  10. XM_039090864.2 → XP_038946792.1  RAB11-binding protein RELCH isoform X11

    Conserved Domains (2) summary
    smart00667
    Location:255 → 287
    LisH; Lissencephaly type-1-like homology motif
    sd00044
    Location:575 → 597
    HEAT; HEAT repeat [structural motif]

  11. XM_039090862.2 → XP_038946790.1  RAB11-binding protein RELCH isoform X10

    Conserved Domains (1) summary
    sd00044
    Location:264 → 293
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_005492251.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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