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Tubgcp2 tubulin gamma complex component 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309098, updated on 2-Nov-2024

Summary

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Official Symbol
Tubgcp2provided by RGD
Official Full Name
tubulin gamma complex component 2provided by RGD
Primary source
RGD:1309597
See related
EnsemblRapid:ENSRNOG00000018137 AllianceGenome:RGD:1309597
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in several processes, including meiotic cell cycle; microtubule cytoskeleton organization; and nervous system development. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of gamma-tubulin complex. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 155.0), Thymus (RPKM 111.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tubgcp2 in Genome Data Viewer
Location:
1q41
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (204220725..204247460, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194791113..194817807, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (212333740..212359352, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sperm flagellar protein 1-like Neighboring gene ADAM metallopeptidase domain 8 Neighboring gene uncharacterized LOC134485200 Neighboring gene 60S ribosomal protein L36-like Neighboring gene zinc finger protein 511 Neighboring gene 5'-nucleotidase, cytosolic IIIA, pseudogene 1 Neighboring gene msh homeobox 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, et al. Pflugers Arch, 2005 Oct. PMID 16025302
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-tubulin complex component 2
Names
a disintegrin and metalloprotease domain 8
tubulin, gamma complex associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107560.2 → NP_001101030.1  gamma-tubulin complex component 2

    See identical proteins and their annotated locations for NP_001101030.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166857
    UniProtKB/TrEMBL
    A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
    Related
    ENSRNOP00000024573.3, ENSRNOT00000024573.6
    Conserved Domains (2) summary
    pfam04130
    Location:509 → 868
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:218 → 506
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    204220725..204247460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263839.1 → XP_063119909.1  gamma-tubulin complex component 2 isoform X2

  2. XM_006230457.4 → XP_006230519.1  gamma-tubulin complex component 2 isoform X1

    See identical proteins and their annotated locations for XP_006230519.1

    UniProtKB/TrEMBL
    A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
    Conserved Domains (2) summary
    pfam04130
    Location:509 → 868
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:218 → 506
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  3. XM_006230460.4 → XP_006230522.1  gamma-tubulin complex component 2 isoform X1

    See identical proteins and their annotated locations for XP_006230522.1

    UniProtKB/TrEMBL
    A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
    Conserved Domains (2) summary
    pfam04130
    Location:509 → 868
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:218 → 506
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  4. XM_006230458.3 → XP_006230520.1  gamma-tubulin complex component 2 isoform X1

    See identical proteins and their annotated locations for XP_006230520.1

    UniProtKB/TrEMBL
    A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
    Conserved Domains (2) summary
    pfam04130
    Location:509 → 868
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:218 → 506
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  5. XM_006230459.5 → XP_006230521.1  gamma-tubulin complex component 2 isoform X1

    See identical proteins and their annotated locations for XP_006230521.1

    UniProtKB/TrEMBL
    A0A8I6B530, A6HXD6, B2RYP8, F7EQB3
    Conserved Domains (2) summary
    pfam04130
    Location:509 → 868
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:218 → 506
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  6. XM_039078900.2 → XP_038934828.1  gamma-tubulin complex component 2 isoform X4

    Conserved Domains (2) summary
    pfam04130
    Location:214 → 573
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:1 → 211
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  7. XM_063263843.1 → XP_063119913.1  gamma-tubulin complex component 2 isoform X3

    Related
    ENSRNOP00000096948.1, ENSRNOT00000105932.2

RNA

  1. XR_010053003.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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