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Pgghg protein-glucosylgalactosylhydroxylysine glucosidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 309103, updated on 2-Nov-2024

Summary

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Official Symbol
Pgghgprovided by RGD
Official Full Name
protein-glucosylgalactosylhydroxylysine glucosidaseprovided by RGD
Primary source
RGD:1306015
See related
EnsemblRapid:ENSRNOG00000014783 AllianceGenome:RGD:1306015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Athl1; RGD1306015
Summary
Predicted to enable protein-glucosylgalactosylhydroxylysine glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in cytosol. Orthologous to human PGGHG (protein-glucosylgalactosylhydroxylysine glucosidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 100.4), Thymus (RPKM 90.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pgghg in Genome Data Viewer
Location:
1q41
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205467179..205474185)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196038276..196044561)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213734198..213743233)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase, subunit VIIIb Neighboring gene NLR family, pyrin domain containing 6 Neighboring gene interferon induced transmembrane protein 5 Neighboring gene interferon induced transmembrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Catalytic site of human protein-glucosylgalactosylhydroxylysine glucosidase: Three crucial carboxyl residues were determined by cloning and site-directed mutagenesis. Hamazaki H, et al. Biochem Biophys Res Commun, 2016 Jan 15. PMID 26682924
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-glucosylgalactosylhydroxylysine glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glucosylgalactosylhydroxylysine glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acid trehalase-like protein 1; protein-glucosylgalactosylhydroxylysine glucosidase
Names
ATH1, acid trehalase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432266.1 → NP_001419195.1  acid trehalase-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HXL9, D3ZY02

  2. NM_001432267.1 → NP_001419196.1  acid trehalase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HXM0

RNA

  1. NR_197278.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  2. NR_197279.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205467179..205474185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230587.5 → XP_006230649.2  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1

    Related
    ENSRNOP00000020004.7, ENSRNOT00000020004.10
    Conserved Domains (2) summary
    COG1554
    Location:95 → 616
    ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
    pfam03632
    Location:291 → 603
    Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain

  2. XM_063279694.1 → XP_063135764.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X2

    UniProtKB/TrEMBL
    A6HXM0

RNA

  1. XR_005494647.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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