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Slc25a22 solute carrier family 25 member 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309111, updated on 6-Jun-2024

Summary

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Symbol
Slc25a22provided by RGD
Full Name
solute carrier family 25 member 22provided by RGD
Primary source
RGD:1307826
See related
Ensembl:ENSRNOG00000049944 AllianceGenome:RGD:1307826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GC1; GC-1; RGD1307826
Summary
Predicted to enable L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 3. Orthologous to human SLC25A22 (solute carrier family 25 member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 127.0), Brain (RPKM 113.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a22 in Genome Data Viewer
Location:
1q41
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205954713..205966188, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196528471..196536398, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214410388..214418236, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transaldolase 1 Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene p53-induced death domain protein 1 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene ribosomal protein lateral stalk subunit P2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. Casimir M, et al. J Biol Chem, 2009 Sep 11. PMID 19584051, Free PMC Article
  2. Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. Fiermonte G, et al. J Biol Chem, 2002 May 31. PMID 11897791
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. insulin-secreting cells depend on GC1 for maximal glucose response.
    Title: Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109527

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial glutamate carrier 1
Names
glutamate/H(+) symporter 1
mitochondrial glutamate carrier 1-like
solute carrier family 25 (mitochondrial carrier, glutamate), member 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014027.1 → NP_001014049.1  mitochondrial glutamate carrier 1

    See identical proteins and their annotated locations for NP_001014049.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090010
    UniProtKB/TrEMBL
    Q5FVG4
    Related
    ENSRNOP00000051753.2, ENSRNOT00000054869.5
    Conserved Domains (1) summary
    pfam00153
    Location:4 → 98
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205954713..205966188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263993.1 → XP_063120063.1  mitochondrial glutamate carrier 1 isoform X1

  2. XM_063264006.1 → XP_063120076.1  mitochondrial glutamate carrier 1 isoform X1

  3. XM_063264072.1 → XP_063120142.1  mitochondrial glutamate carrier 1 isoform X3

  4. XM_063263977.1 → XP_063120047.1  mitochondrial glutamate carrier 1 isoform X1

  5. XM_063264011.1 → XP_063120081.1  mitochondrial glutamate carrier 1 isoform X1

  6. XM_063264023.1 → XP_063120093.1  mitochondrial glutamate carrier 1 isoform X1

  7. XM_063264021.1 → XP_063120091.1  mitochondrial glutamate carrier 1 isoform X1

  8. XM_063263984.1 → XP_063120054.1  mitochondrial glutamate carrier 1 isoform X1

  9. XM_063264002.1 → XP_063120072.1  mitochondrial glutamate carrier 1 isoform X1

  10. XM_063264015.1 → XP_063120085.1  mitochondrial glutamate carrier 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTG5

  11. XM_063263968.1 → XP_063120038.1  mitochondrial glutamate carrier 1 isoform X1

  12. XM_063264057.1 → XP_063120127.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5

  13. XM_039079016.2 → XP_038934944.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:4 → 98
    Mito_carr; Mitochondrial carrier protein

  14. XM_039078995.2 → XP_038934923.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5
    Related
    ENSRNOP00000073467.1
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:4 → 98
    Mito_carr; Mitochondrial carrier protein

  15. XM_039079022.2 → XP_038934950.1  mitochondrial glutamate carrier 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JTG5
    Conserved Domains (1) summary
    pfam00153
    Location:57 → 166
    Mito_carr; Mitochondrial carrier protein

  16. XM_063264049.1 → XP_063120119.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5

  17. XM_063264046.1 → XP_063120116.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5

  18. XM_063264024.1 → XP_063120094.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5

  19. XM_063264029.1 → XP_063120099.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5

  20. XM_039079019.2 → XP_038934947.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:4 → 98
    Mito_carr; Mitochondrial carrier protein

  21. XM_017589233.3 → XP_017444722.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:4 → 98
    Mito_carr; Mitochondrial carrier protein

  22. XM_063264077.1 → XP_063120147.1  mitochondrial glutamate carrier 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JTG5

  23. XM_063264078.1 → XP_063120148.1  mitochondrial glutamate carrier 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JTG5

  24. XM_039079009.2 → XP_038934937.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:4 → 98
    Mito_carr; Mitochondrial carrier protein

  25. XM_063264056.1 → XP_063120126.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5

  26. XM_039079004.2 → XP_038934932.1  mitochondrial glutamate carrier 1 isoform X2

    UniProtKB/Swiss-Prot
    A0A0G2K5L2, D3ZRF5, Q5FVG4
    UniProtKB/TrEMBL
    A0A0G2JTG5
    Related
    ENSRNOP00000068705.2
    Conserved Domains (2) summary
    PTZ00169
    Location:3 → 289
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:4 → 98
    Mito_carr; Mitochondrial carrier protein

  27. XM_063264081.1 → XP_063120151.1  mitochondrial glutamate carrier 1 isoform X6

    UniProtKB/TrEMBL
    A6HXX1

  28. XM_063264080.1 → XP_063120150.1  mitochondrial glutamate carrier 1 isoform X6

    UniProtKB/TrEMBL
    A6HXX1

  29. XM_063264079.1 → XP_063120149.1  mitochondrial glutamate carrier 1 isoform X5

  30. XM_063264082.1 → XP_063120152.1  mitochondrial glutamate carrier 1 isoform X7

    UniProtKB/TrEMBL
    A6HXX5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0G2K5L2.1 GenPept UniProtKB/Swiss-Prot:A0A0G2K5L2

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