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Cracr2b calcium release activated channel regulator 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 309112, updated on 14-Nov-2024

Summary

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Symbol
Cracr2bprovided by RGD
Full Name
calcium release activated channel regulator 2Bprovided by RGD
Primary source
RGD:1560911
See related
EnsemblRapid:ENSRNOG00000019199 AllianceGenome:RGD:1560911
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Efcab4a; RGD1560911
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in store-operated calcium entry. Predicted to act upstream of or within regulation of store-operated calcium entry. Predicted to be located in cytoplasm. Orthologous to human CRACR2B (calcium release activated channel regulator 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 89.2), Kidney (RPKM 51.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cracr2b in Genome Data Viewer
Location:
1q41
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205987957..205993515)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196558407..196563961)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214439810..214445876)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene CD151 molecule (Raph blood group) Neighboring gene RNA polymerase II, I and III subunit L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Srikanth S, et al. Nat Cell Biol, 2010 May. PMID 20418871, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
involved_in store-operated calcium entry ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 4A
Names
EF-hand calcium binding domain 4A
EF-hand calcium-binding domain-containing protein 4A-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127541.2 → NP_001121013.1  EF-hand calcium-binding domain-containing protein 4A

    See identical proteins and their annotated locations for NP_001121013.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    B0BNK9
    Conserved Domains (2) summary
    pfam08614
    Location:229 → 303
    ATG16; Autophagy protein 16 (ATG16)
    pfam13499
    Location:31 → 88
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205987957..205993515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230561.5 → XP_006230623.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    See identical proteins and their annotated locations for XP_006230623.1

    UniProtKB/Swiss-Prot
    B0BNK9
    Conserved Domains (2) summary
    pfam08614
    Location:229 → 303
    ATG16; Autophagy protein 16 (ATG16)
    pfam13499
    Location:31 → 88
    EF-hand_7; EF-hand domain pair

  2. XM_063264083.1 → XP_063120153.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    UniProtKB/Swiss-Prot
    B0BNK9

  3. XM_063264085.1 → XP_063120155.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    UniProtKB/Swiss-Prot
    B0BNK9

  4. XM_063264090.1 → XP_063120160.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    UniProtKB/Swiss-Prot
    B0BNK9

  5. XM_006230559.5 → XP_006230621.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    See identical proteins and their annotated locations for XP_006230621.1

    UniProtKB/Swiss-Prot
    B0BNK9
    Related
    ENSRNOP00000025964.4, ENSRNOT00000025964.7
    Conserved Domains (2) summary
    pfam08614
    Location:229 → 303
    ATG16; Autophagy protein 16 (ATG16)
    pfam13499
    Location:31 → 88
    EF-hand_7; EF-hand domain pair

  6. XM_039079038.2 → XP_038934966.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    UniProtKB/Swiss-Prot
    B0BNK9
    Conserved Domains (2) summary
    pfam08614
    Location:229 → 303
    ATG16; Autophagy protein 16 (ATG16)
    pfam13499
    Location:31 → 88
    EF-hand_7; EF-hand domain pair

  7. XM_039079062.2 → XP_038934990.1  EF-hand calcium-binding domain-containing protein 4A isoform X2

    UniProtKB/TrEMBL
    A6HXY9
    Conserved Domains (2) summary
    TIGR02168
    Location:40 → 205
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam08614
    Location:113 → 187
    ATG16; Autophagy protein 16 (ATG16)

  8. XM_039079078.2 → XP_038935006.1  EF-hand calcium-binding domain-containing protein 4A isoform X3

    Conserved Domains (1) summary
    PRK11448
    Location:55 → 147
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional

  9. XM_039079053.2 → XP_038934981.1  EF-hand calcium-binding domain-containing protein 4A isoform X2

    UniProtKB/TrEMBL
    A6HXY9
    Conserved Domains (2) summary
    TIGR02168
    Location:40 → 205
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam08614
    Location:113 → 187
    ATG16; Autophagy protein 16 (ATG16)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BNK9.1 GenPept UniProtKB/Swiss-Prot:B0BNK9

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