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H19 H19 imprinted maternally expressed transcript [ Rattus norvegicus (Norway rat) ]

Gene ID: 309122, updated on 2-Nov-2024

Summary

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Official Symbol
H19provided by RGD
Official Full Name
H19 imprinted maternally expressed transcriptprovided by RGD
Primary source
RGD:2775
See related
AllianceGenome:RGD:2775
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ASM; ASM1; D11S813E
Summary
Involved in several processes, including negative regulation of cytokine production; positive regulation of cardiac muscle cell proliferation; and regulation of apoptotic process. Used to study acute myocardial infarction; dilated cardiomyopathy; middle cerebral artery infarction; and myocardial infarction. Biomarker of hepatocellular carcinoma; middle cerebral artery infarction; pre-eclampsia; and transitional cell carcinoma. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 33876.1) and Liver (RPKM 5195.4) See more
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Genomic context

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See H19 in Genome Data Viewer
Location:
1q41
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (207160175..207162851, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197730698..197733374, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215744404..215747080, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene troponin T3, fast skeletal type Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized LOC102548505 Neighboring gene microRNA 675 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene microRNA 483 Neighboring gene insulin-like growth factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy. Wang J, et al. Aging Dis, 2017 Feb. PMID 28203482, Free PMC Article
  2. Gene expression in the bladder carcinoma rat model. Ariel I, et al. Mol Carcinog, 2004 Oct. PMID 15378645
  3. Study of long non-coding RNA and mitochondrial dysfunction in diabetic rats. Sultan HK, et al. Tissue Cell, 2021 Aug. PMID 33744742
  4. Hormonal regulation of H19 gene expression in prostate epithelial cells. Berteaux N, et al. J Endocrinol, 2004 Oct. PMID 15525575
  5. Long Noncoding RNA H19 Overexpression Protects against Hypoxic-Ischemic Brain Damage by Inhibiting miR-107 and Up-Regulating Vascular Endothelial Growth Factor. Fang H, et al. Am J Pathol, 2021 Mar. PMID 33608066

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis.
    Title: Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis.
  2. Long Non-coding RNA H19 Promotes NLRP3-Mediated Pyroptosis After Subarachnoid Hemorrhage in Rats.
    Title: Long Non-coding RNA H19 Promotes NLRP3-Mediated Pyroptosis After Subarachnoid Hemorrhage in Rats.
  3. The interplay between H19 and HIF-1alpha in mitochondrial dysfunction in myocardial infarction.
    Title: The interplay between H19 and HIF-1α in mitochondrial dysfunction in myocardial infarction.
  4. [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
    Title: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
  5. Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.
    Title: Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.
  6. The Long Noncoding RNA H19 Promotes Fibrotic Processes in Lens Epithelial Cells.
    Title: The Long Noncoding RNA H19 Promotes Fibrotic Processes in Lens Epithelial Cells.
  7. LncRNA H19 Regulates P-glycoprotein Expression Through the NF-kappaB Signaling Pathway in the Model of Status Epilepticus.
    Title: LncRNA H19 Regulates P-glycoprotein Expression Through the NF-κB Signaling Pathway in the Model of Status Epilepticus.
  8. H19 silencing decreases kainic acid-induced hippocampus neuron injury via activating the PI3K/AKT pathway via the H19/miR-206 axis.
    Title: H19 silencing decreases kainic acid-induced hippocampus neuron injury via activating the PI3K/AKT pathway via the H19/miR-206 axis.
  9. Mechanisms Underlying Abnormal Expression of lncRNA H19 in Neonatal Hypoxic-Ischemic Encephalopathy.
    Title: Mechanisms Underlying Abnormal Expression of lncRNA H19 in Neonatal Hypoxic-Ischemic Encephalopathy.
  10. Long non-coding RNA H19 alleviates hippocampal damage in convulsive status epilepticus rats through the nuclear factor-kappaB signaling pathway.
    Title: Long non-coding RNA H19 alleviates hippocampal damage in convulsive status epilepticus rats through the nuclear factor-kappaB signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (56)

General gene information

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Markers

Other Names

  • H19 fetal liver mRNA
  • H19, imprinted maternally expressed transcript (non-protein coding)

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within genomic imprinting ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mesenchymal to epithelial transition IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in response to alkaloid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027324.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC160921, CV121279

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    207160175..207162851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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