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Tnpo1 transportin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309126, updated on 28-Oct-2024

Summary

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Official Symbol
Tnpo1provided by RGD
Official Full Name
transportin 1provided by RGD
Primary source
RGD:1308372
See related
EnsemblRapid:ENSRNOG00000014999 AllianceGenome:RGD:1308372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 275.3), Adrenal (RPKM 268.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnpo1 in Genome Data Viewer
Location:
2q12
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31941731..32034366, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (30207529..30300162, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (29056219..29126882, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 171 Neighboring gene Histone deacetylase 1, pseudogene 8 Neighboring gene FCH and mu domain containing endocytic adaptor 2 Neighboring gene eukaryotic translation initiation factor 5B like Neighboring gene H2B.L histone variant 1 Neighboring gene uncharacterized LOC134485826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Bonifaci N, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144189, Free PMC Article
  2. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
  3. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transportin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100692.2 → NP_001094162.1  transportin-1 isoform b

    See identical proteins and their annotated locations for NP_001094162.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6AG33, F1LQP9
    Related
    ENSRNOP00000020543.8, ENSRNOT00000020543.9
    Conserved Domains (2) summary
    COG5215
    Location:24 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95 → 116
    HEAT; HEAT repeat [structural motif]

  2. NM_001399431.1 → NP_001386360.1  transportin-1 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    Related
    ENSRNOP00000093625.2, ENSRNOT00000099589.2
    Conserved Domains (2) summary
    COG5215
    Location:32 → 767
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:103 → 124
    HEAT; HEAT repeat [structural motif]

  3. NM_001399432.1 → NP_001386361.1  transportin-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6AG33
    Related
    ENSRNOP00000092200.1, ENSRNOT00000110663.2
    Conserved Domains (2) summary
    COG5215
    Location:24 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95 → 116
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    31941731..32034366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102145.2 → XP_038958073.1  transportin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AG33, F1LQP9
    Conserved Domains (2) summary
    COG5215
    Location:24 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95 → 116
    HEAT; HEAT repeat [structural motif]

  2. XM_039102144.2 → XP_038958072.1  transportin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AG33, F1LQP9
    Conserved Domains (2) summary
    COG5215
    Location:24 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95 → 116
    HEAT; HEAT repeat [structural motif]

  3. XM_006231840.5 → XP_006231902.1  transportin-1 isoform X1

    See identical proteins and their annotated locations for XP_006231902.1

    UniProtKB/TrEMBL
    A0A8I6AG33, F1LQP9
    Conserved Domains (2) summary
    COG5215
    Location:24 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95 → 116
    HEAT; HEAT repeat [structural motif]

  4. XM_008760668.4 → XP_008758890.1  transportin-1 isoform X1

    See identical proteins and their annotated locations for XP_008758890.1

    UniProtKB/TrEMBL
    A0A8I6AG33, F1LQP9
    Conserved Domains (2) summary
    COG5215
    Location:24 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95 → 116
    HEAT; HEAT repeat [structural motif]

  5. XM_063281688.1 → XP_063137758.1  transportin-1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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