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Ppp6r3 protein phosphatase 6, regulatory subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309144, updated on 2-Nov-2024

Summary

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Symbol
Ppp6r3provided by RGD
Full Name
protein phosphatase 6, regulatory subunit 3provided by RGD
Primary source
RGD:1307145
See related
EnsemblRapid:ENSRNOG00000015540 AllianceGenome:RGD:1307145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Saps3; Saps3-ps1; Ppp6r3-ps1; RGD1307145
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 259.3), Thymus (RPKM 231.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp6r3 in Genome Data Viewer
Location:
1q42
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210122394..210236839, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (200693128..200807578, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218695738..218810139, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483953 Neighboring gene testis expressed metallothionein like protein Neighboring gene galanin and GMAP prepropeptide Neighboring gene RNA, U6 small nuclear 993 Neighboring gene transfer RNA asparagine (anticodon GUU) 1 Neighboring gene UTP3, small subunit processome component, pseudogene 1 Neighboring gene apolipoprotein A-II like 1 Neighboring gene LDL receptor related protein 5 Neighboring gene 40S ribosomal protein S9 pseudogene Neighboring gene uncharacterized LOC134483954

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of the Rho GTPase-activating protein RICS in neurite outgrowth. Nasu-Nishimura Y, et al. Genes Cells, 2006 Jun. PMID 16716191
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 3
Names
SAPS domain family, member 3, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395099.1 → NP_001382028.1  serine/threonine-protein phosphatase 6 regulatory subunit 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HYL2
    Related
    ENSRNOP00000020886.8, ENSRNOT00000020886.9
    Conserved Domains (2) summary
    PRK13108
    Location:734 → 866
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210122394..210236839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264253.1 → XP_063120323.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

  2. XM_039079308.2 → XP_038935236.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    UniProtKB/TrEMBL
    F1MAH5
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  3. XM_017589247.3 → XP_017444736.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    UniProtKB/TrEMBL
    A6HYL0
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  4. XM_017589246.3 → XP_017444735.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

  5. XM_039079344.2 → XP_038935272.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

    UniProtKB/TrEMBL
    A6HYL1, D3ZBT9
    Conserved Domains (2) summary
    PRK13108
    Location:705 → 837
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  6. XM_039079339.2 → XP_038935267.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    Related
    ENSRNOP00000062399.4, ENSRNOT00000065950.6
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  7. XM_039079331.2 → XP_038935259.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    Conserved Domains (2) summary
    PRK13108
    Location:717 → 849
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  8. XM_017589243.3 → XP_017444732.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

  9. XM_039079325.2 → XP_038935253.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    Conserved Domains (2) summary
    PRK13108
    Location:728 → 860
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  10. XM_039079321.2 → XP_038935249.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  11. XM_008760128.3 → XP_008758350.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_008758350.1

    UniProtKB/TrEMBL
    F1MAH5
    Related
    ENSRNOP00000107832.1, ENSRNOT00000129761.1
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  12. XM_008760131.3 → XP_008758353.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

    See identical proteins and their annotated locations for XP_008758353.1

    UniProtKB/TrEMBL
    A6HYL2
    Conserved Domains (2) summary
    PRK13108
    Location:734 → 866
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  13. XM_063264249.1 → XP_063120319.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

  14. XM_008760129.3 → XP_008758351.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_008758351.1

    UniProtKB/TrEMBL
    F1MAH5
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  15. XM_063264225.1 → XP_063120295.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    UniProtKB/TrEMBL
    F1MAH5

  16. XM_063264241.1 → XP_063120311.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

    UniProtKB/TrEMBL
    A6HYL2

  17. XM_039079349.2 → XP_038935277.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001287134.1: Suppressed sequence

    Description
    NM_001287134.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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