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Cdc42ep2 CDC42 effector protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309175, updated on 2-Nov-2024

Summary

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Official Symbol
Cdc42ep2provided by RGD
Official Full Name
CDC42 effector protein 2provided by RGD
Primary source
RGD:1310253
See related
EnsemblRapid:ENSRNOG00000020904 AllianceGenome:RGD:1310253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity; opioid peptide activity; and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in several cellular components, including cytosol; microtubule cytoskeleton; and phagocytic vesicle. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human CDC42EP2 (CDC42 effector protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 113.7), Heart (RPKM 87.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdc42ep2 in Genome Data Viewer
Location:
1q43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212631317..212640231, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203202000..203210891, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221272349..221281252, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tigger transposable element derived 3 Neighboring gene double PHD fingers 2 Neighboring gene 40S ribosomal protein S27-like Neighboring gene DNA polymerase alpha 2, accessory subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. Burbelo PD, et al. Proc Natl Acad Sci U S A, 1999 Aug 3. PMID 10430899, Free PMC Article
  2. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
  3. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
  4. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94615

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables opioid peptide activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pseudopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cdc42 effector protein 2
Names
CDC42 effector protein (Rho GTPase binding) 2
binder of Rho GTPases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009689.1 → NP_001009689.1  cdc42 effector protein 2

    See identical proteins and their annotated locations for NP_001009689.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087091
    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Conserved Domains (2) summary
    pfam14957
    Location:103 → 206
    BORG_CEP; Cdc42 effector
    cl00113
    Location:29 → 87
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212631317..212640231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264396.1 → XP_063120466.1  cdc42 effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Related
    ENSRNOP00000103944.1, ENSRNOT00000148088.1

  2. XM_006230806.5 → XP_006230868.1  cdc42 effector protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006230868.1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Related
    ENSRNOP00000028379.4, ENSRNOT00000028379.7
    Conserved Domains (2) summary
    pfam14957
    Location:103 → 206
    BORG_CEP; Cdc42 effector
    cl00113
    Location:29 → 87
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  3. XM_017589254.3 → XP_017444743.1  cdc42 effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Conserved Domains (2) summary
    pfam14957
    Location:103 → 206
    BORG_CEP; Cdc42 effector
    cl00113
    Location:29 → 87
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  4. XM_017589255.3 → XP_017444744.1  cdc42 effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Conserved Domains (2) summary
    pfam14957
    Location:103 → 206
    BORG_CEP; Cdc42 effector
    cl00113
    Location:29 → 87
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  5. XM_017589252.3 → XP_017444741.1  cdc42 effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Related
    ENSRNOP00000079453.1, ENSRNOT00000096503.2
    Conserved Domains (2) summary
    pfam14957
    Location:103 → 206
    BORG_CEP; Cdc42 effector
    cl00113
    Location:29 → 87
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  6. XM_039079669.2 → XP_038935597.1  cdc42 effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Conserved Domains (2) summary
    pfam14957
    Location:103 → 206
    BORG_CEP; Cdc42 effector
    cl00113
    Location:29 → 87
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  7. XM_017589253.3 → XP_017444742.1  cdc42 effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Related
    ENSRNOP00000103126.1, ENSRNOT00000124089.1
    Conserved Domains (2) summary
    pfam14957
    Location:103 → 206
    BORG_CEP; Cdc42 effector
    cl00113
    Location:29 → 87
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

  8. XM_063264388.1 → XP_063120458.1  cdc42 effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQP4
    UniProtKB/TrEMBL
    A6HZB3
    Related
    ENSRNOP00000095646.1, ENSRNOT00000105520.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQP4.1 GenPept UniProtKB/Swiss-Prot:Q5PQP4

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