U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Taf6l TATA-box binding protein associated factor 6 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 309194, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Taf6lprovided by RGD
Official Full Name
TATA-box binding protein associated factor 6 likeprovided by RGD
Primary source
RGD:1310123
See related
EnsemblRapid:ENSRNOG00000019419 AllianceGenome:RGD:1310123
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; regulation of DNA-templated transcription; and regulation of somatic stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of SAGA complex. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 64.4), Thymus (RPKM 52.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Taf6l in Genome Data Viewer
Location:
1q43
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215101266..215113888, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205672147..205684721, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224974238..224986819, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 223 Neighboring gene transmembrane protein 179B Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene RNA polymerase II subunit G Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene tetratricopeptide repeat domain 9C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Seruggia D, et al. Mol Cell, 2019 Jun 20. PMID 31005419, Free PMC Article
  2. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article
  3. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
  4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Names
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107575.1 → NP_001101045.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

    See identical proteins and their annotated locations for NP_001101045.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215101266..215113888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230982.5 → XP_006231044.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    See identical proteins and their annotated locations for XP_006231044.1

    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  2. XM_008760224.4 → XP_008758446.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    See identical proteins and their annotated locations for XP_008758446.1

    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  3. XM_006230981.5 → XP_006231043.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    See identical proteins and their annotated locations for XP_006231043.1

    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  4. XM_039079710.2 → XP_038935638.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  5. XM_006230979.5 → XP_006231041.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    See identical proteins and their annotated locations for XP_006231041.1

    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Related
    ENSRNOP00000026284.6, ENSRNOT00000026284.9
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  6. XM_017589259.3 → XP_017444748.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  7. XM_039079711.2 → XP_038935639.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARN5, A0A9K3Y8B8, B5DF37, F7F938
    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 372
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

  8. XM_063264420.1 → XP_063120490.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y8B8, B5DF37, F7F938

  9. XM_039079714.2 → XP_038935642.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X2

    Conserved Domains (2) summary
    pfam02969
    Location:16 → 80
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:160 → 370
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools