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Ints5 integrator complex subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309200, updated on 17-Aug-2024

Summary

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Official Symbol
Ints5provided by RGD
Official Full Name
integrator complex subunit 5provided by RGD
Primary source
RGD:1309370
See related
AllianceGenome:RGD:1309370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309370
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of integrator complex. Orthologous to human INTS5 (integrator complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 64.2), Spleen (RPKM 61.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ints5 in Genome Data Viewer
Location:
1q43
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215218012..215222790)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205788906..205793685)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225091612..225096390)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA57 Neighboring gene similar to human chromosome 11 open reading frame 98 Neighboring gene uncharacterized LOC102551607 Neighboring gene glucosidase II alpha subunit Neighboring gene beta-1,3-glucuronyltransferase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrator complex subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107576.1 → NP_001101046.1  integrator complex subunit 5

    See identical proteins and their annotated locations for NP_001101046.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6HZX2, D3ZTW1
    Conserved Domains (2) summary
    pfam14837
    Location:29 → 251
    INTS5_N; Integrator complex subunit 5 N-terminus
    pfam14838
    Location:290 → 999
    INTS5_C; Integrator complex subunit 5 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215218012..215222790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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