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Ms4a1 membrane spanning 4-domains A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309217, updated on 2-Nov-2024

Summary

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Official Symbol
Ms4a1provided by RGD
Official Full Name
membrane spanning 4-domains A1provided by RGD
Primary source
RGD:1311999
See related
EnsemblRapid:ENSRNOG00000020945 AllianceGenome:RGD:1311999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cd20
Summary
Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and positive regulation of calcium ion import across plasma membrane. Predicted to act upstream of or within response to bacterium. Predicted to be located in cell surface; nucleoplasm; and plasma membrane raft. Predicted to be active in external side of plasma membrane. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in common variable immunodeficiency 5. Orthologous to human MS4A1 (membrane spanning 4-domains A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 916.9) and Thymus (RPKM 119.5) See more
Orthologs
human mouse all
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Genomic context

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See Ms4a1 in Genome Data Viewer
Location:
1q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (217331274..217351934, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207906370..207927028, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (227429241..227441492, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A13 Neighboring gene uncharacterized LOC120093141 Neighboring gene 60S ribosomal protein L6 pseudogene Neighboring gene membrane spanning 4-domains A12 Neighboring gene membrane spanning 4-domains A5 Neighboring gene membrane spanning 4-domains A14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Current and emerging treatments for chronic lymphocytic leukaemia. Robak T, et al. Drugs, 2009. PMID 19911856
  2. Characterization of the mononuclear cell infiltrate in the glomerulus of rats with glomerulonephritis. Radounikli A, et al. Nephrol Dial Transplant, 1995. PMID 7538648
  3. Mouse CD20 expression and function. Uchida J, et al. Int Immunol, 2004 Jan. PMID 14688067
  4. Store-operated cation entry mediated by CD20 in membrane rafts. Li H, et al. J Biol Chem, 2003 Oct 24. PMID 12920111
  5. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. Bubien JK, et al. J Cell Biol, 1993 Jun. PMID 7684739, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in calcium ion import into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
B-lymphocyte antigen CD20
Names
membrane-spanning 4-domains, subfamily A, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399452.1 → NP_001386381.1  B-lymphocyte antigen CD20

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D4A4Y3
    Related
    ENSRNOP00000028433.6, ENSRNOT00000028433.9
    Conserved Domains (1) summary
    pfam04103
    Location:51 → 217
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    217331274..217351934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079860.2 → XP_038935788.1  B-lymphocyte antigen CD20 isoform X1

    UniProtKB/TrEMBL
    A6I085, D4A4Y3
    Conserved Domains (1) summary
    pfam04103
    Location:51 → 217
    CD20; CD20-like family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107578.1: Suppressed sequence

    Description
    NM_001107578.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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