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Otud7a OTU deubiquitinase 7A [ Rattus norvegicus (Norway rat) ]

Gene ID: 309252, updated on 10-Jul-2024

Summary

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Official Symbol
Otud7aprovided by RGD
Official Full Name
OTU deubiquitinase 7Aprovided by RGD
Primary source
RGD:1563721
See related
EnsemblRapid:ENSRNOG00000015503 AllianceGenome:RGD:1563721
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563721
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein K11-linked deubiquitination. Orthologous to human OTUD7A (OTU deubiquitinase 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 64.1), Lung (RPKM 24.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Otud7a in Genome Data Viewer
Location:
1q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (126476275..126800037)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117064428..117388217)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (124311873..124655437)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548165 Neighboring gene uncharacterized LOC102548323 Neighboring gene ribosomal protein L36, pseudogene Neighboring gene high mobility group nucleosome binding domain 5B Neighboring gene ribosomal protein L7a, pseudogene 34 Neighboring gene uncharacterized LOC134483597 Neighboring gene small nucleolar RNA U3 Neighboring gene KLF transcription factor 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, et al. Cell, 2013 Jul 3. PMID 23827681, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 7A
Names
OTU domain containing 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    126476275..126800037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278750.1 → XP_063134820.1  OTU domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    D4ABZ4

  2. XM_008759566.4 → XP_008757788.1  OTU domain-containing protein 7A isoform X3

    See identical proteins and their annotated locations for XP_008757788.1

    UniProtKB/TrEMBL
    D4ABZ4
    Related
    ENSRNOP00000110596.1, ENSRNOT00000139392.1
    Conserved Domains (3) summary
    cd14347
    Location:26 → 68
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:899 → 922
    zf-A20; A20-like zinc finger
    cl19932
    Location:207 → 378
    OTU; OTU-like cysteine protease

  3. XM_063278759.1 → XP_063134829.1  OTU domain-containing protein 7A isoform X2

    UniProtKB/TrEMBL
    D4ABZ4

  4. XM_008759568.4 → XP_008757790.1  OTU domain-containing protein 7A isoform X4

    UniProtKB/TrEMBL
    D4ABZ4
    Conserved Domains (3) summary
    cd14347
    Location:26 → 68
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:898 → 921
    zf-A20; A20-like zinc finger
    cl19932
    Location:206 → 377
    OTU; OTU-like cysteine protease

  5. XM_063278751.1 → XP_063134821.1  OTU domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    D4ABZ4

  6. XM_063278757.1 → XP_063134827.1  OTU domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    D4ABZ4
Nucleotide Protein Strain
Heading Accession and Version

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