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Uhrf2 ubiquitin like with PHD and ring finger domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309331, updated on 2-Nov-2024

Summary

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Official Symbol
Uhrf2provided by RGD
Official Full Name
ubiquitin like with PHD and ring finger domains 2provided by RGD
Primary source
RGD:1309990
See related
EnsemblRapid:ENSRNOG00000011308 AllianceGenome:RGD:1309990
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; histone binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including negative regulation of gene expression via chromosomal CpG island methylation; protein autoubiquitination; and regulation of cell cycle. Predicted to be located in nucleoplasm and pericentric heterochromatin. Orthologous to human UHRF2 (ubiquitin like with PHD and ring finger domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 340.5), Thymus (RPKM 243.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uhrf2 in Genome Data Viewer
Location:
1q52
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (237224050..237291406)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227814639..227877907)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (248228496..248291984)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100019 Neighboring gene TPD52 like 3 Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 3 Neighboring gene glycine decarboxylase Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways. Pichler G, et al. J Cell Biochem, 2011 Sep. PMID 21598301, Free PMC Article
  2. NIRF induces G1 arrest and associates with Cdk2. Li Y, et al. Biochem Biophys Res Commun, 2004 Jun 25. PMID 15178429
  3. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Mori T, et al. Biochem Biophys Res Commun, 2002 Aug 23. PMID 12176013
  4. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. Mori T, et al. FEBS Lett, 2004 Jan 16. PMID 14741369
  5. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA, et al. Epigenetics, 2013 Feb. PMID 23324617, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase UHRF2
Names
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
ubiquitin-like, containing PHD and RING finger domains 2
NP_001101055.1
XP_038935936.1
XP_038935940.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107585.1 → NP_001101055.1  E3 ubiquitin-protein ligase UHRF2

    See identical proteins and their annotated locations for NP_001101055.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6I0X9, D3ZK36
    Related
    ENSRNOP00000015406.4, ENSRNOT00000015406.7
    Conserved Domains (6) summary
    cd01797
    Location:1 → 76
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00213
    Location:3 → 74
    UBQ; Ubiquitin homologues
    cd00162
    Location:733 → 776
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15617
    Location:347 → 393
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:447 → 615
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:126 → 313
    TTD; Tandem tudor domain within UHRF1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    237224050..237291406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080012.2 → XP_038935940.1  E3 ubiquitin-protein ligase UHRF2 isoform X2

    Conserved Domains (4) summary
    cd15617
    Location:347 → 393
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    cd17123
    Location:1 → 74
    Ubl_UHRF2; ubiquitin-like (Ubl) domain found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:447 → 538
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:126 → 313
    TTD; Tandem tudor domain within UHRF1

  2. XM_039080008.2 → XP_038935936.1  E3 ubiquitin-protein ligase UHRF2 isoform X1

    Conserved Domains (5) summary
    COG5222
    Location:478 → 579
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd15617
    Location:123 → 169
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    cd16613
    Location:508 → 553
    RING-HC_UHRF; RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing proteins, UHRF1 and UHRF2, and similar proteins
    pfam02182
    Location:223 → 391
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:1 → 89
    TTD; Tandem tudor domain within UHRF1

RNA

  1. XR_005486766.2 RNA Sequence

  2. XR_005486773.2 RNA Sequence

  3. XR_005486776.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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