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Pyroxd2 pyridine nucleotide-disulphide oxidoreductase domain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309381, updated on 2-Nov-2024

Summary

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Official Symbol
Pyroxd2provided by RGD
Official Full Name
pyridine nucleotide-disulphide oxidoreductase domain 2provided by RGD
Primary source
RGD:1303232
See related
EnsemblRapid:ENSRNOG00000015807 AllianceGenome:RGD:1303232
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1303232
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial matrix. Orthologous to human PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 614.1), Adrenal (RPKM 74.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pyroxd2 in Genome Data Viewer
Location:
1q54
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (251472609..251498316, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (241523278..241549083, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261961164..261987029, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484050 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene TD and POZ domain containing 1, pseudogene 20 Neighboring gene HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 Neighboring gene heparanase 2 (inactive)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC94853

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
Names
Phytn_dehydro and Pyr_redox domain containing protein RGD1303232

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004261.1 → NP_001004261.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

    See identical proteins and their annotated locations for NP_001004261.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079368
    UniProtKB/Swiss-Prot
    Q68FT3
    UniProtKB/TrEMBL
    A0A8L2QB18
    Related
    ENSRNOP00000021257.5, ENSRNOT00000021257.6
    Conserved Domains (3) summary
    COG1233
    Location:33 → 571
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    pfam13450
    Location:39 → 84
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:278 → 578
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    251472609..251498316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760424.4 → XP_008758646.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QB18
    Conserved Domains (3) summary
    COG1233
    Location:33 → 559
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    pfam13450
    Location:39 → 84
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:278 → 559
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_006231394.5 → XP_006231456.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8L2QB18
    Related
    ENSRNOP00000100434.1, ENSRNOT00000153698.1
    Conserved Domains (3) summary
    COG1233
    Location:33 → 559
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    pfam13450
    Location:39 → 84
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:278 → 559
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_039080124.2 → XP_038936052.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    COG1233
    Location:16 → 525
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

  4. XM_006231396.5 → XP_006231458.1  pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8L2QB18
    Conserved Domains (3) summary
    COG1233
    Location:33 → 537
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    pfam13450
    Location:39 → 84
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:278 → 514
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_005486952.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FT3.1 GenPept UniProtKB/Swiss-Prot:Q68FT3

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