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Pttg1 pituitary tumor-transforming gene 1 [ Mus musculus (house mouse) ]

Gene ID: 30939, updated on 28-Oct-2024

Summary

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Official Symbol
Pttg1provided by MGI
Official Full Name
pituitary tumor-transforming gene 1provided by MGI
Primary source
MGI:MGI:1353578
See related
Ensembl:ENSMUSG00000020415 AllianceGenome:MGI:1353578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pttg; Pttg3
Summary
Enables cysteine-type endopeptidase inhibitor activity. Acts upstream of or within homologous chromosome segregation; mitotic sister chromatid cohesion; and smoothened signaling pathway. Located in cytoplasm and nucleus. Is active in axoneme. Is expressed in several structures, including central nervous system; eye; limb; mesonephric tubule of male; and testis. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 18.7), testis adult (RPKM 15.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Pttg1 in Genome Data Viewer
Location:
11 B1.1; 11 25.68 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43311097..43317417, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43420244..43427463, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 146 Neighboring gene STARR-positive B cell enhancer ABC_E9138 Neighboring gene predicted gene 5782 Neighboring gene STARR-positive B cell enhancer ABC_E3940 Neighboring gene STARR-positive B cell enhancer ABC_E6968 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene predicted gene 12151

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Wang Z, et al. Proc Natl Acad Sci U S A, 2003 Mar 18. PMID 12626748, Free PMC Article
  2. Pituitary senescence: the evolving role of Pttg. Chesnokova V, et al. Mol Cell Endocrinol, 2010 Sep 15. PMID 20153804, Free PMC Article
  3. Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs. Nabti I, et al. Dev Biol, 2008 Sep 15. PMID 18639540
  4. Characterization of the pituitary tumor transforming gene 1 knockout mouse retina. Yetemian RM, et al. Neurochem Res, 2011 Apr. PMID 21203837, Free PMC Article
  5. Pituitary tumor transforming gene (PTTG) transforming and transactivation activity. Wang Z, et al. J Biol Chem, 2000 Mar 17. PMID 10713046

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.
    Title: MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.
  2. PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.
    Title: PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.
  3. PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
    Title: PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
  4. The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
    Title: The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
  5. Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.
    Title: Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.
  6. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
    Title: A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
  7. The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.
    Title: The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.
  8. The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss.
    Title: Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.
  9. Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
    Title: Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.
  10. High PTTG1 expression is associated with pituitary tumor development.
    Title: mTOR promotes pituitary tumor development through activation of PTTG1.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (8)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in homologous chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homologous chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within smoothened signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
securin
Names
pituitary tumor-transforming 1
pituitary tumor-transforming gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131054.3 → NP_001124526.1  securin isoform 1

    See identical proteins and their annotated locations for NP_001124526.1

    Status: VALIDATED

    Source sequence(s)
    AL670472
    Consensus CDS
    CCDS48771.1
    UniProtKB/Swiss-Prot
    O88887, Q9CQJ7, Q9Z2E6
    UniProtKB/TrEMBL
    Q3Y5K4
    Related
    ENSMUSP00000020687.9, ENSMUST00000020687.15
    Conserved Domains (1) summary
    pfam04856
    Location:1 → 188
    Securin; Securin sister-chromatid separation inhibitor

  2. NM_001362799.2 → NP_001349728.1  securin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670472
    Consensus CDS
    CCDS48771.1
    UniProtKB/Swiss-Prot
    O88887, Q9CQJ7, Q9Z2E6
    UniProtKB/TrEMBL
    Q3Y5K4
    Related
    ENSMUSP00000098894.5, ENSMUST00000101340.11
    Conserved Domains (1) summary
    pfam04856
    Location:1 → 188
    Securin; Securin sister-chromatid separation inhibitor

  3. NM_001425538.1 → NP_001412467.1  securin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670472
    UniProtKB/Swiss-Prot
    O88887, Q9CQJ7, Q9Z2E6
    Related
    ENSMUSP00000112834.2, ENSMUST00000118368.8

  4. NM_001425539.1 → NP_001412468.1  securin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670472
    UniProtKB/Swiss-Prot
    O88887, Q9CQJ7, Q9Z2E6
    Related
    ENSMUSP00000112815.2, ENSMUST00000121638.8

  5. NM_001425540.1 → NP_001412469.1  securin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670472
    UniProtKB/Swiss-Prot
    O88887, Q9CQJ7, Q9Z2E6

  6. NM_001425541.1 → NP_001412470.1  securin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670472
    UniProtKB/Swiss-Prot
    O88887, Q9CQJ7, Q9Z2E6

  7. NM_001425542.1 → NP_001412471.1  securin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670472

  8. NM_001425543.1 → NP_001412472.1  securin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670472

  9. NM_001425544.1 → NP_001412473.1  securin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670472

  10. NM_001425545.1 → NP_001412474.1  securin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670472

  11. NM_001425546.1 → NP_001412475.1  securin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670472

  12. NM_001425547.1 → NP_001412476.1  securin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670472
    Related
    ENSMUSP00000020685.10, ENSMUST00000020685.10

  13. NM_001425548.1 → NP_001412477.1  securin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670472

  14. NM_001425549.1 → NP_001412478.1  securin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670472

  15. NM_001425550.1 → NP_001412479.1  securin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670472

  16. NM_001425551.1 → NP_001412480.1  securin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670472

  17. NM_001425552.1 → NP_001412481.1  securin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670472

  18. NM_001425553.1 → NP_001412482.1  securin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670472

  19. NM_013917.4 → NP_038945.2  securin isoform 2

    See identical proteins and their annotated locations for NP_038945.2

    Status: VALIDATED

    Source sequence(s)
    AL670472
    Consensus CDS
    CCDS24556.1
    UniProtKB/TrEMBL
    Q3Y5K4
    Related
    ENSMUSP00000112841.2, ENSMUST00000117446.8
    Conserved Domains (1) summary
    pfam04856
    Location:1 → 173
    Securin; Securin sister-chromatid separation inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    43311097..43317417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQJ7.1 GenPept UniProtKB/Swiss-Prot:Q9CQJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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