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Hnf4g hepatocyte nuclear factor 4, gamma [ Mus musculus (house mouse) ]

Gene ID: 30942, updated on 2-Nov-2024

Summary

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Official Symbol
Hnf4gprovided by MGI
Official Full Name
hepatocyte nuclear factor 4, gammaprovided by MGI
Primary source
MGI:MGI:1353604
See related
Ensembl:ENSMUSG00000017688 AllianceGenome:MGI:1353604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NR2A2
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; and nervous system. Orthologous to human HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 18.4), small intestine adult (RPKM 7.7) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Hnf4g in Genome Data Viewer
Location:
3 A1; 3 1.82 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (3573090..3724863)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (3508030..3659800)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA lysine 31 (anticodon CTT) Neighboring gene STARR-seq mESC enhancer starr_06769 Neighboring gene RAB3 GTPase activating protein subunit 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06770 Neighboring gene STARR-seq mESC enhancer starr_06771 Neighboring gene STARR-seq mESC enhancer starr_06773 Neighboring gene STARR-seq mESC enhancer starr_06774 Neighboring gene STARR-seq mESC enhancer starr_06775 Neighboring gene STARR-seq mESC enhancer starr_06776 Neighboring gene STARR-seq mESC enhancer starr_06777 Neighboring gene STARR-seq mESC enhancer starr_06779 Neighboring gene STARR-seq mESC enhancer starr_06780 Neighboring gene ribosomal protein S24, pseudogene 2 Neighboring gene POU domain, class 5, transcription factor 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice. Gerdin AK, et al. Biochem Biophys Res Commun, 2006 Oct 20. PMID 16945327
  2. Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption. Ayari S, et al. J Endocrinol, 2021 Nov 24. PMID 34647524
  3. Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma. Taraviras S, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786614
  4. Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage. Baraille F, et al. Diabetes, 2015 Aug. PMID 25829452
  5. Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g. Thymiakou E, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2022 Mar. PMID 34973414

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.
    Title: Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.
  2. HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.
    Title: HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.
  3. Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption.
    Title: Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption.
  4. Genetic inactivation of Hnf4a and its paralog Hnf4g revealed that HNF4 factors are redundantly required for fetal maturation.
    Title: HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.
  5. HNF4A acts redundantly with an intestine-restricted HNF4 paralog, HNF4G, to activate enhancer chromatin and upregulate the majority of transcripts in the differentiated epithelium; cells fail to differentiate on double knockout of both HNF4 paralogs. Furthermore, we show that SMAD4 and HNF4 function via a reinforcing feed-forward loop.
    Title: A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.
  6. the loss of HNF-4gamma improves glucose homeostasis through a modulation of the enteroendocrine cell lineage.
    Title: Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage.
  7. HNF4g has a role in energy expenditure, locomotor activity during night time, and higher body weight
    Title: Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte nuclear factor 4-gamma
Names
HNF-4-gamma
nuclear receptor subfamily 2 group A member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395870.1 → NP_001382799.1  hepatocyte nuclear factor 4-gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157926, AC170259
    UniProtKB/TrEMBL
    E9QPS1, Q059V1
    Related
    ENSMUSP00000104031.2, ENSMUST00000108394.4
    Conserved Domains (2) summary
    cd06931
    Location:157 → 378
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:66 → 141
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  2. NM_013920.3 → NP_038948.2  hepatocyte nuclear factor 4-gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157764, AC157926, AC170259
    Consensus CDS
    CCDS17226.1
    UniProtKB/Swiss-Prot
    Q9WUU6
    UniProtKB/TrEMBL
    Q059V1
    Related
    ENSMUSP00000104030.3, ENSMUST00000108393.9
    Conserved Domains (2) summary
    cd06931
    Location:103 → 324
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:12 → 87
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    3573090..3724863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUU6.2 GenPept UniProtKB/Swiss-Prot:Q9WUU6

Gene LinkOut

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