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Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309451, updated on 2-Nov-2024

Summary

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Official Symbol
Gbf1provided by RGD
Official Full Name
golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by RGD
Primary source
RGD:1307160
See related
EnsemblRapid:ENSRNOG00000026048 AllianceGenome:RGD:1307160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307160
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and protein localization to organelle. Located in Golgi stack; endoplasmic reticulum lumen; and peroxisome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 169.8), Heart (RPKM 139.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gbf1 in Genome Data Viewer
Location:
1q54
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254959784..255088479)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245018535..245147052)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265904616..266033107)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain 3 Neighboring gene ATP synthase membrane subunit g, pseudogene 12 Neighboring gene uncharacterized LOC134484079 Neighboring gene U6 spliceosomal RNA Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 7 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene uncharacterized LOC134484075

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1. García-Mata R, et al. Mol Biol Cell, 2003 Jun. PMID 12808027, Free PMC Article
  2. GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat. Kawamoto K, et al. Traffic, 2002 Jul. PMID 12047556
  3. AMPK phosphorylates GBF1 for mitotic Golgi disassembly. Mao L, et al. J Cell Sci, 2013 Mar 15. PMID 23418352
  4. Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Zhao X, et al. Mol Biol Cell, 2002 Jan. PMID 11809827, Free PMC Article
  5. Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking. Szul T, et al. J Cell Sci, 2007 Nov 15. PMID 17956946

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum-Golgi intermediate compartment organization ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of monopolar cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Names
golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1
golgi-specific brefeldin A-resistance factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191634.1 → NP_001178563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JHL5
    Conserved Domains (3) summary
    COG5307
    Location:483 → 1162
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain
    pfam12783
    Location:400 → 545
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    254959784..255088479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231500.5 → XP_006231562.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X8

    UniProtKB/TrEMBL
    A6JHL5
    Related
    ENSRNOP00000038037.7, ENSRNOT00000036156.7
    Conserved Domains (3) summary
    COG5307
    Location:484 → 1163
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700 → 885
    Sec7; Sec7 domain
    pfam12783
    Location:401 → 546
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  2. XM_006231501.5 → XP_006231563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X9

    UniProtKB/TrEMBL
    A6JHL5, F1M8X9
    Conserved Domains (3) summary
    COG5307
    Location:484 → 1163
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700 → 885
    Sec7; Sec7 domain
    pfam12783
    Location:401 → 546
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  3. XM_006231502.5 → XP_006231564.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X10

    UniProtKB/TrEMBL
    A6JHL5
    Conserved Domains (3) summary
    COG5307
    Location:483 → 1162
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain
    pfam12783
    Location:400 → 545
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  4. XM_039080486.2 → XP_038936414.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5

    UniProtKB/TrEMBL
    A6JHL5
    Conserved Domains (4) summary
    PHA03247
    Location:1756 → 1886
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:510 → 1029
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:726 → 911
    Sec7; Sec7 domain
    pfam12783
    Location:427 → 572
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  5. XM_006231496.5 → XP_006231558.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    A6JHL5
    Conserved Domains (2) summary
    pfam01369
    Location:733 → 918
    Sec7; Sec7 domain
    pfam12783
    Location:434 → 579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  6. XM_006231497.5 → XP_006231559.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    A6JHL5
    Conserved Domains (2) summary
    pfam01369
    Location:732 → 917
    Sec7; Sec7 domain
    pfam12783
    Location:433 → 578
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  7. XM_039080492.2 → XP_038936420.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6

    UniProtKB/TrEMBL
    A6JHL5
    Conserved Domains (4) summary
    PHA03247
    Location:1755 → 1885
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:509 → 1028
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:725 → 910
    Sec7; Sec7 domain
    pfam12783
    Location:426 → 571
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  8. XM_063264977.1 → XP_063121047.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X11

  9. XM_063264979.1 → XP_063121049.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X12

    Related
    ENSRNOP00000102549.1, ENSRNOT00000149376.1

  10. XM_006231498.5 → XP_006231560.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

    UniProtKB/TrEMBL
    A6JHL5
    Conserved Domains (2) summary
    pfam01369
    Location:733 → 918
    Sec7; Sec7 domain
    pfam12783
    Location:434 → 579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  11. XM_063264948.1 → XP_063121018.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

  12. XM_063264959.1 → XP_063121029.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

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