Neurl1 neuralized E3 ubiquitin protein ligase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neurl1provided by RGD
Official Full Name: neuralized E3 ubiquitin protein ligase 1provided by RGD
Primary source: RGD:1307021
See related: EnsemblRapid:ENSRNOG00000020339 AllianceGenome:RGD:1307021
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Neurl; Neurl1a
Summary: Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in skeletal muscle tissue development. Predicted to be located in cytoplasm; dendrite; and perikaryon. Predicted to be active in glutamatergic synapse; plasma membrane; and postsynaptic density. Biomarker of visual epilepsy. Orthologous to human NEURL1 (neuralized E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 96.0), Brain (RPKM 69.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (256008012..256094219)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (246066830..246152890)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266953006..267038879)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A.
Title: Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A.
endogenous NEURL1 mRNAs with both longer and shorter 3'UTRs are enriched in the neurites of cultured rat primary hippocampal neurons. Both NEURL1 3'UTRs can mediate transport of reporter mRNAs into dendrites in primary hippocampal neurons.
Title: Rat NEURL1 3'UTR is alternatively spliced and targets mRNA to dendrites.

Submit: New GeneRIF Correction

General gene information

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Markers

BE097027 (e-PCR)
- UniSTS:244590

D1Rat452 (e-PCR), detects polymorphism
- UniSTS:227234

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables translation factor activity, non-nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sperm axoneme assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NEURL1

Names: neuralized homolog 1A; neuralized-like homolog; neuralized-like protein 1A

NP_001101075.1

EC 2.3.2.27

NP_001388553.1

EC 2.3.2.27

XP_006231573.1

EC 2.3.2.27

XP_006231574.1

EC 2.3.2.27

XP_063121146.1

EC 2.3.2.27

XP_063121148.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107605.1 → NP_001101075.1 E3 ubiquitin-protein ligase NEURL1 isoform 2

See identical proteins and their annotated locations for NP_001101075.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A6JHQ2, D3ZZE6

Related

ENSRNOP00000051580.2, ENSRNOT00000054696.4

Conserved Domains (3) summary

smart00588
Location:61 → 183

NEUZ; domain in neuralized proteins

pfam07177
Location:65 → 130

Neuralized; Neuralized

cl02614
Location:65 → 213

SPRY; SPRY domain
NM_001401624.1 → NP_001388553.1 E3 ubiquitin-protein ligase NEURL1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZN22, A6JHQ1

Related

ENSRNOP00000079455.1, ENSRNOT00000112299.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

256008012..256094219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265076.1 → XP_063121146.1 E3 ubiquitin-protein ligase NEURL1 isoform X3

Related

ENSRNOP00000103765.1, ENSRNOT00000165645.1
XM_006231511.5 → XP_006231573.1 E3 ubiquitin-protein ligase NEURL1 isoform X1

UniProtKB/TrEMBL

A0A096MJM7

Related

ENSRNOP00000068189.2, ENSRNOT00000076452.4

Conserved Domains (4) summary

smart00588
Location:44 → 166

NEUZ; domain in neuralized proteins

pfam07177
Location:48 → 113

Neuralized; Neuralized

pfam13920
Location:501 → 550

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl02614
Location:278 → 429

SPRY; SPRY domain
XM_063265078.1 → XP_063121148.1 E3 ubiquitin-protein ligase NEURL1 isoform X4
XM_006231512.5 → XP_006231574.1 E3 ubiquitin-protein ligase NEURL1 isoform X2

Related

ENSRNOP00000106458.1, ENSRNOT00000129899.1

Conserved Domains (4) summary

smart00588
Location:41 → 163

NEUZ; domain in neuralized proteins

pfam07177
Location:45 → 110

Neuralized; Neuralized

pfam13920
Location:498 → 547

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl02614
Location:275 → 426

SPRY; SPRY domain