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Atad1 ATPase family, AAA domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309532, updated on 19-Sep-2024

Summary

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Official Symbol
Atad1provided by RGD
Official Full Name
ATPase family, AAA domain containing 1provided by RGD
Primary source
RGD:1308570
See related
EnsemblRapid:ENSRNOG00000010861 AllianceGenome:RGD:1308570
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-088
Summary
Predicted to enable ATP binding activity and transmembrane protein dislocase activity. Predicted to be involved in several processes, including extraction of mislocalized protein from mitochondrial outer membrane; learning or memory; and regulation of receptor internalization. Predicted to be located in mitochondrial outer membrane; peroxisomal membrane; and postsynaptic membrane. Predicted to be active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 378.0), Muscle (RPKM 288.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atad1 in Genome Data Viewer
Location:
1q52
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239957329..240023792, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (230544227..230610524, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (251234702..251386996, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485221 Neighboring gene U2 spliceosomal RNA Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene uncharacterized LOC134485222 Neighboring gene glutathione S-transferase P 1-like Neighboring gene phosphatase and tensin homolog Neighboring gene uncharacterized LOC102547905 Neighboring gene aldo-keto reductase family 1, member B8, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Zhang J, et al. Cell, 2011 Apr 15. PMID 21496646, Free PMC Article
  2. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
  3. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables membrane protein dislocase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in extraction of mislocalized protein from mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extraction of mislocalized protein from mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in extraction of mislocalized protein from mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in learning ISO
Inferred from Sequence Orthology
more info
  
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
outer mitochondrial transmembrane helix translocase
Names
ATPase family AAA domain-containing protein 1
neuroprotective protein 6
thorase
NP_001030174.1
XP_038936585.1
XP_038936590.1
XP_038936599.1
XP_038936607.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035002.1 → NP_001030174.1  outer mitochondrial transmembrane helix translocase

    See identical proteins and their annotated locations for NP_001030174.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094514
    UniProtKB/Swiss-Prot
    B3STU2, Q505J9
    UniProtKB/TrEMBL
    A6I109
    Related
    ENSRNOP00000014684.5, ENSRNOT00000014684.9
    Conserved Domains (2) summary
    pfam17862
    Location:282 → 321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92 → 257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    239957329..240023792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080657.2 → XP_038936585.1  outer mitochondrial transmembrane helix translocase isoform X1

    UniProtKB/Swiss-Prot
    B3STU2, Q505J9
    UniProtKB/TrEMBL
    A6I109
    Conserved Domains (2) summary
    pfam17862
    Location:282 → 321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92 → 257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

  2. XM_039080662.2 → XP_038936590.1  outer mitochondrial transmembrane helix translocase isoform X1

    UniProtKB/Swiss-Prot
    B3STU2, Q505J9
    UniProtKB/TrEMBL
    A6I109
    Conserved Domains (2) summary
    pfam17862
    Location:282 → 321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92 → 257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

  3. XM_039080671.2 → XP_038936599.1  outer mitochondrial transmembrane helix translocase isoform X1

    UniProtKB/Swiss-Prot
    B3STU2, Q505J9
    UniProtKB/TrEMBL
    A6I109
    Conserved Domains (2) summary
    pfam17862
    Location:282 → 321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92 → 257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

  4. XM_039080679.2 → XP_038936607.1  outer mitochondrial transmembrane helix translocase isoform X2

    Conserved Domains (2) summary
    pfam17862
    Location:224 → 263
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:34 → 199
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q505J9.1 GenPept UniProtKB/Swiss-Prot:Q505J9

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