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Epb41l2 erythrocyte membrane protein band 4.1-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309557, updated on 10-Jul-2024

Summary

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Official Symbol
Epb41l2provided by RGD
Official Full Name
erythrocyte membrane protein band 4.1-like 2provided by RGD
Primary source
RGD:1563977
See related
EnsemblRapid:ENSRNOG00000012346 AllianceGenome:RGD:1563977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Epb4.1l2; RGD1563977
Summary
Predicted to enable PH domain binding activity and spectrin binding activity. Predicted to be involved in actomyosin structure organization and positive regulation of protein localization to cell cortex. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of COP9 signalosome. Predicted to be active in cytoskeleton and plasma membrane. Orthologous to human EPB41L2 (erythrocyte membrane protein band 4.1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 186.7), Testes (RPKM 104.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Epb41l2 in Genome Data Viewer
Location:
1p12
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (21682336..21857106, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (19863010..20037795, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (20881820..21067713, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 9 Neighboring gene uncharacterized LOC134482583 Neighboring gene small leucine-rich protein 1 Neighboring gene uncharacterized LOC102552728 Neighboring gene cyclin B2, pseudogene 2 Neighboring gene A-kinase anchoring protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. 4.1G promotes arborization and tight junction formation of oligodendrocyte cell line OLN-93. Xia W, et al. J Cell Physiol, 2012 Jun. PMID 21898413
  2. Cytoskeletal protein 4.1G is a binding partner of the metabotropic glutamate receptor subtype 1 alpha. Lu D, et al. J Neurosci Res, 2004 Oct 1. PMID 15372499
  3. Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action. Lu D, et al. Biochem J, 2004 Jan 1. PMID 12974671, Free PMC Article
  4. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. Kontrogianni-Konstantopoulos A, et al. J Biol Chem, 2001 Jun 8. PMID 11274145
  5. Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Kiyomitsu T, et al. Cell, 2013 Jul 18. PMID 23870127, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest functional roles of 4.1G/Epb4.112 in cellular arborization and tight junction formation in oligodendrocytes.
    Title: 4.1G promotes arborization and tight junction formation of oligodendrocyte cell line OLN-93.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PH domain binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
band 4.1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400827.1 → NP_001387756.1  band 4.1-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KU05, D3ZDT1
    Related
    ENSRNOP00000017322.5, ENSRNOT00000017322.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    21682336..21857106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099066.2 → XP_038954994.1  band 4.1-like protein 2 isoform X1

    Conserved Domains (6) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:622 → 662
    SAB; SAB domain
    pfam05902
    Location:959 → 1064
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  2. XM_039099143.2 → XP_038955071.1  band 4.1-like protein 2 isoform X27

    UniProtKB/TrEMBL
    D3ZAY2
    Conserved Domains (5) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:604 → 691
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  3. XM_039099134.2 → XP_038955062.1  band 4.1-like protein 2 isoform X25

    UniProtKB/TrEMBL
    D3ZAY7
    Conserved Domains (5) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:706 → 795
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  4. XM_039099128.2 → XP_038955056.1  band 4.1-like protein 2 isoform X24

    Conserved Domains (5) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:731 → 836
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  5. XM_063265513.1 → XP_063121583.1  band 4.1-like protein 2 isoform X21

  6. XM_063265508.1 → XP_063121578.1  band 4.1-like protein 2 isoform X20

  7. XM_039099123.2 → XP_038955051.1  band 4.1-like protein 2 isoform X16

    Conserved Domains (5) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:844 → 949
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  8. XM_039099119.2 → XP_038955047.1  band 4.1-like protein 2 isoform X14

    Conserved Domains (5) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:863 → 968
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  9. XM_063265458.1 → XP_063121528.1  band 4.1-like protein 2 isoform X12

  10. XM_063265521.1 → XP_063121591.1  band 4.1-like protein 2 isoform X23

  11. XM_063265473.1 → XP_063121543.1  band 4.1-like protein 2 isoform X18

  12. XM_063265461.1 → XP_063121531.1  band 4.1-like protein 2 isoform X13

  13. XM_063265514.1 → XP_063121584.1  band 4.1-like protein 2 isoform X22

  14. XM_063265422.1 → XP_063121492.1  band 4.1-like protein 2 isoform X2

    Related
    ENSRNOP00000101515.1, ENSRNOT00000166148.1

  15. XM_063265468.1 → XP_063121538.1  band 4.1-like protein 2 isoform X15

  16. XM_039099113.2 → XP_038955041.1  band 4.1-like protein 2 isoform X10

    UniProtKB/TrEMBL
    A6KU04, D3ZM69
    Related
    ENSRNOP00000058049.3, ENSRNOT00000061332.7
    Conserved Domains (6) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:622 → 662
    SAB; SAB domain
    pfam05902
    Location:884 → 989
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  17. XM_039099103.2 → XP_038955031.1  band 4.1-like protein 2 isoform X8

    Conserved Domains (6) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:622 → 662
    SAB; SAB domain
    pfam05902
    Location:903 → 1008
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  18. XM_063265470.1 → XP_063121540.1  band 4.1-like protein 2 isoform X17

  19. XM_063265452.1 → XP_063121522.1  band 4.1-like protein 2 isoform X11

  20. XM_063265433.1 → XP_063121503.1  band 4.1-like protein 2 isoform X6

  21. XM_063265431.1 → XP_063121501.1  band 4.1-like protein 2 isoform X5

  22. XM_039099094.2 → XP_038955022.1  band 4.1-like protein 2 isoform X7

    Related
    ENSRNOP00000104039.1, ENSRNOT00000149297.1
    Conserved Domains (6) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:622 → 662
    SAB; SAB domain
    pfam05902
    Location:914 → 1019
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  23. XM_063265440.1 → XP_063121510.1  band 4.1-like protein 2 isoform X9

  24. XM_039099083.2 → XP_038955011.1  band 4.1-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K162
    Related
    ENSRNOP00000103905.1, ENSRNOT00000166769.1
    Conserved Domains (6) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:622 → 662
    SAB; SAB domain
    pfam05902
    Location:933 → 1038
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  25. XM_039099076.2 → XP_038955004.1  band 4.1-like protein 2 isoform X3

    Related
    ENSRNOP00000071713.3, ENSRNOT00000079688.3
    Conserved Domains (6) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:622 → 662
    SAB; SAB domain
    pfam05902
    Location:936 → 1041
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  26. XM_063265477.1 → XP_063121547.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  27. XM_063265386.1 → XP_063121456.1  band 4.1-like protein 2 isoform X1

  28. XM_063265430.1 → XP_063121500.1  band 4.1-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K162

  29. XM_063265551.1 → XP_063121621.1  band 4.1-like protein 2 isoform X27

    UniProtKB/TrEMBL
    D3ZAY2
    Related
    ENSRNOP00000017417.5, ENSRNOT00000017417.7

  30. XM_017589862.3 → XP_017445351.1  band 4.1-like protein 2 isoform X25

    UniProtKB/TrEMBL
    D3ZAY7
    Related
    ENSRNOP00000017412.5, ENSRNOT00000017412.8
    Conserved Domains (5) summary
    PTZ00121
    Location:4 → 216
    PTZ00121; MAEBL; Provisional
    smart00295
    Location:215 → 404
    B41; Band 4.1 homologues
    cd13184
    Location:399 → 492
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam05902
    Location:706 → 795
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:502 → 545
    FA; FERM adjacent (FA)

  31. XM_063265444.1 → XP_063121514.1  band 4.1-like protein 2 isoform X10

    UniProtKB/TrEMBL
    A6KU04, D3ZM69

  32. XM_063265492.1 → XP_063121562.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  33. XM_063265547.1 → XP_063121617.1  band 4.1-like protein 2 isoform X27

    UniProtKB/TrEMBL
    D3ZAY2

  34. XM_063265540.1 → XP_063121610.1  band 4.1-like protein 2 isoform X26

  35. XM_063265490.1 → XP_063121560.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  36. XM_063265395.1 → XP_063121465.1  band 4.1-like protein 2 isoform X1

  37. XM_063265376.1 → XP_063121446.1  band 4.1-like protein 2 isoform X1

  38. XM_063265545.1 → XP_063121615.1  band 4.1-like protein 2 isoform X27

    UniProtKB/TrEMBL
    D3ZAY2

  39. XM_063265480.1 → XP_063121550.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  40. XM_063265475.1 → XP_063121545.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  41. XM_063265451.1 → XP_063121521.1  band 4.1-like protein 2 isoform X10

    UniProtKB/TrEMBL
    A6KU04, D3ZM69

  42. XM_063265495.1 → XP_063121565.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  43. XM_063265483.1 → XP_063121553.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  44. XM_063265403.1 → XP_063121473.1  band 4.1-like protein 2 isoform X1

  45. XM_063265418.1 → XP_063121488.1  band 4.1-like protein 2 isoform X1

  46. XM_063265501.1 → XP_063121571.1  band 4.1-like protein 2 isoform X19

    UniProtKB/TrEMBL
    A6KU05, D3ZDT1

  47. XM_063265410.1 → XP_063121480.1  band 4.1-like protein 2 isoform X1

  48. XM_063265449.1 → XP_063121519.1  band 4.1-like protein 2 isoform X10

    UniProtKB/TrEMBL
    A6KU04, D3ZM69

  49. XM_063265510.1 → XP_063121580.1  band 4.1-like protein 2 isoform X20

Nucleotide Protein Strain
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