Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk8ip3provided by MGI
Official Full Name: mitogen-activated protein kinase 8 interacting protein 3provided by MGI
Primary source: MGI:MGI:1353598
See related: Ensembl:ENSMUSG00000024163 AllianceGenome:MGI:1353598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jip3; Syd2; JIP-3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; D17Wsu15e; mKIAA1066
Summary: Enables MAP-kinase scaffold activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of neuron migration; and regulation of MAPK cascade. Acts upstream of or within several processes, including JNK cascade; lung development; and nervous system development. Located in several cellular components, including Golgi membrane; axolemma; and smooth endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; pancreas; retina; and spleen. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 61.4), cortex adult (RPKM 55.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.53 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25116480..25155951, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24897506..24936977, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 is a critical regulator for arthritis progression by meditating inflammation in mice model.
Title: c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 is a critical regulator for arthritis progression by meditating inflammation in mice model.
JIP3-KO mice after aortic banding exhibited attenuated cardiac function, reduced fibrosis levels and decreased hypertrophic marker proteins. Loss of JIP3 also ameliorated oxidative stress, inflammatory response, apoptosis and endoplasmic reticulum (ER) stress in hearts.
Title: JIP3 deficiency attenuates cardiac hypertrophy by suppression of JNK pathway.
JIP3 absence is associated with decreased lipogenesis, oxidative stress and inflammation, supplying a new target for nonalcoholic fatty liver disease treatment.
Title: JIP3 knockout protects mice against high fat diet-induced liver injury.
These results establish the critical role of JIP3-dependent axonal lysosome transport in regulating amyloidogenic amyloid precursor protein processing and support a model wherein Abeta production is amplified by plaque-induced axonal lysosome transport defects.
Title: Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.
Data show that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport.
Title: JIP3 regulates neuronal radial migration by mediating TrkB axonal anterograde transport in the developing cerebral cortex.
JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration
Title: JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.
Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures
Title: Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
These findings reveal that JIP3 regulation of kinesin-1 motility is critical for axon elongation and regeneration.
Title: JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation.
JSAP1 and JLP, which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 localization to the midbody by forming a tripartite complex of JSAP1/JLP, active ARF6, and kinesin-1.
Title: JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.
JIP3 regulates neuronal axon elongation in a kinesin- and JNK-dependent manner
Title: c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143979 (e-PCR)
- UniSTS:233225

D17Wsu15e (e-PCR), detects polymorphism
- UniSTS:142171

RH124588 (e-PCR)
- UniSTS:161410

D17Jcs40 (e-PCR), detects polymorphism
- UniSTS:259281

BB120594 (e-PCR)
- UniSTS:186090

AI413736 (e-PCR)
- UniSTS:180975

PMC311134P1 (e-PCR)
- UniSTS:272894

PMC311134P2 (e-PCR)
- UniSTS:272895

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP-kinase scaffold activity	IPI Inferred from Physical Interaction more info	PubMed
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinesin binding	IDA Inferred from Direct Assay more info	PubMed
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde axonal protein transport	ISO Inferred from Sequence Orthology more info
involved_in axon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 3

Names: JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JUN/SAPK-associated protein 1; c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; sunday driver 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163447.1 → NP_001156919.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform b

See identical proteins and their annotated locations for NP_001156919.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.

Source sequence(s)

AC166102

Consensus CDS

CCDS50024.1

UniProtKB/TrEMBL

Q6NV54

Related

ENSMUSP00000114084.2, ENSMUST00000120035.8

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:416 → 484

JIP_LZII; JNK-interacting protein leucine zipper II
NM_001163448.1 → NP_001156920.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform c

See identical proteins and their annotated locations for NP_001156920.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform c) compared to isoform a.

Source sequence(s)

AC166102, AF178636, BM899006, CO433928

Consensus CDS

CCDS50025.1

UniProtKB/TrEMBL

Q6NV54

Related

ENSMUSP00000110883.3, ENSMUST00000115228.9

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:411 → 479

JIP_LZII; JNK-interacting protein leucine zipper II
NM_001163449.1 → NP_001156921.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform d

See identical proteins and their annotated locations for NP_001156921.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform d) compared to isoform a.

Source sequence(s)

AC166102, BC060603

Consensus CDS

CCDS50029.1

UniProtKB/TrEMBL

Q6P1F1

Related

ENSMUSP00000112712.2, ENSMUST00000117509.8

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:394 → 462

JIP_LZII; JNK-interacting protein leucine zipper II
NM_001163450.1 → NP_001156922.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform e) compared to isoform a.

Source sequence(s)

AC166102

Consensus CDS

CCDS50028.1

UniProtKB/TrEMBL

E9Q6E0, Q6P1F1

Related

ENSMUSP00000113698.2, ENSMUST00000121723.8

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:386 → 454

JIP_LZII; JNK-interacting protein leucine zipper II
NM_001163451.1 → NP_001156923.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform f

See identical proteins and their annotated locations for NP_001156923.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses two alternate in-frame splice sites in the 5' coding region compared to variant 1. This results in a shorter protein (isoform f) compared to isoform a.

Source sequence(s)

AC166102

Consensus CDS

CCDS50026.1

UniProtKB/TrEMBL

Q6P1F1

Related

ENSMUSP00000112955.2, ENSMUST00000119115.8

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:385 → 453

JIP_LZII; JNK-interacting protein leucine zipper II
NM_001163453.1 → NP_001156925.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform g) compared to isoform a.

Source sequence(s)

AC166102, BC065105

Consensus CDS

CCDS50027.1

UniProtKB/TrEMBL

E9Q6B6, Q6P1F1

Related

ENSMUSP00000113753.2, ENSMUST00000121787.8

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:380 → 448

JIP_LZII; JNK-interacting protein leucine zipper II
NM_013931.4 → NP_038959.2 C-Jun-amino-terminal kinase-interacting protein 3 isoform a

See identical proteins and their annotated locations for NP_038959.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC166102, AF262046, AK134797, BM899006

Consensus CDS

CCDS37498.1

UniProtKB/Swiss-Prot

Q5D062, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESN9, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7

UniProtKB/TrEMBL

Q3UHB5, Q6NV54

Related

ENSMUSP00000085683.6, ENSMUST00000088345.12

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:417 → 485

JIP_LZII; JNK-interacting protein leucine zipper II