U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mdc1 mediator of DNA damage checkpoint 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309595, updated on 2-May-2024

Summary

Go to the top of the page Help
Symbol
Mdc1provided by RGD
Full Name
mediator of DNA damage checkpoint 1provided by RGD
Primary source
RGD:1559468
See related
Ensembl:ENSRNOG00000032813 AllianceGenome:RGD:1559468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable FHA domain binding activity and protein C-terminus binding activity. Predicted to be involved in DNA repair. Predicted to be located in chromosome; focal adhesion; and nuclear body. Orthologous to human MDC1 (mediator of DNA damage checkpoint 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 103.5), Spleen (RPKM 88.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mdc1 in Genome Data Viewer
Location:
20p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (2898496..2914960, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2893693..2912394, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3405017..3419831, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 18 Neighboring gene microRNA 6328 Neighboring gene nurim Neighboring gene tubulin, beta 5 class I Neighboring gene flotillin 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma. Zhang ZZ, et al. World J Gastroenterol, 2013 Mar 28. PMID 23569343, Free PMC Article
  2. NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer. Yuan C, et al. Mol Cell Biochem, 2012 Jan. PMID 21853275
  3. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Bartkova J, et al. Oncogene, 2007 Nov 22. PMID 17546051
  4. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Pei H, et al. Nature, 2011 Feb 3. PMID 21293379, Free PMC Article
  5. CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Becherel OJ, et al. Nucleic Acids Res, 2010 Mar. PMID 20008512, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • KIAA0170

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin-protein adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables histone reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mediator of DNA damage checkpoint protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166275.1 → NP_001159747.1  mediator of DNA damage checkpoint protein 1

    See identical proteins and their annotated locations for NP_001159747.1

    Status: VALIDATED

    Source sequence(s)
    BC085955
    UniProtKB/Swiss-Prot
    Q5U2M8, Q6MG15
    Related
    ENSRNOP00000049009.4, ENSRNOT00000046798.5
    Conserved Domains (3) summary
    cd00027
    Location:1099 → 1151
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00498
    Location:55 → 110
    FHA; FHA domain
    pfam00533
    Location:1186 → 1259
    BRCT; BRCA1 C Terminus (BRCT) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    2898496..2914960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098645.2 → XP_038954573.1  mediator of DNA damage checkpoint protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AKS9
    Related
    ENSRNOP00000095067.1
    Conserved Domains (6) summary
    PHA03307
    Location:500 → 868
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:197 → 370
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05109
    Location:791 → 1232
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17744
    Location:1345 → 1415
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1447 → 1526
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    pfam00498
    Location:55 → 110
    FHA; FHA domain

  2. XM_039098643.2 → XP_038954571.1  mediator of DNA damage checkpoint protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GIV7
    Related
    ENSRNOP00000091266.1
    Conserved Domains (6) summary
    PHA03307
    Location:507 → 875
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:204 → 377
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05109
    Location:798 → 1239
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17744
    Location:1352 → 1422
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1454 → 1533
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    pfam00498
    Location:62 → 117
    FHA; FHA domain

  3. XM_039098647.1 → XP_038954575.1  mediator of DNA damage checkpoint protein 1 isoform X3

    Conserved Domains (6) summary
    PHA03307
    Location:507 → 875
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:204 → 377
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05109
    Location:782 → 1006
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17744
    Location:1093 → 1163
    BRCT_MDC1_rpt1; first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    cd18441
    Location:1195 → 1274
    BRCT_MDC1_rpt2; second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins
    pfam00498
    Location:62 → 117
    FHA; FHA domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2M8.2 GenPept UniProtKB/Swiss-Prot:Q5U2M8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous