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Vars2 valyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 309596, updated on 10-Jul-2024

Summary

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Official Symbol
Vars2provided by RGD
Official Full Name
valyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source
RGD:1303122
See related
EnsemblRapid:ENSRNOG00000000833 AllianceGenome:RGD:1303122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Varsl; Vars2l
Summary
Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 43.2), Adrenal (RPKM 43.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vars2 in Genome Data Viewer
Location:
20p12
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3081869..3092907)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3077132..3087994)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3588462..3599514)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene discoidin domain receptor tyrosine kinase 1 Neighboring gene uncharacterized LOC134483850 Neighboring gene general transcription factor 2H subunit 4 Neighboring gene surfactant associated 2 Neighboring gene mucin like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • KIAA1885

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables valine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables valine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables valine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in valyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
valine--tRNA ligase, mitochondrial
Names
valRS
valyl-tRNA synthetase 2, mitochondrial (putative)
valyl-tRNA synthetase, mitochondrial
XP_063135159.1
XP_063135160.1
XP_063135161.1
XP_063135162.1
XP_063135163.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429116.1 → NP_001416045.1  valine--tRNA ligase, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    Q6MG21

  2. NM_001429117.1 → NP_001416046.1  valine--tRNA ligase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    Q6MG21

RNA

  1. NR_190585.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3081869..3092907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279089.1 → XP_063135159.1  valine--tRNA ligase, mitochondrial isoform X1

    Related
    ENSRNOP00000098217.2, ENSRNOT00000048103.7

  2. XM_063279093.1 → XP_063135163.1  valine--tRNA ligase, mitochondrial isoform X5

  3. XM_063279091.1 → XP_063135161.1  valine--tRNA ligase, mitochondrial isoform X3

  4. XM_063279092.1 → XP_063135162.1  valine--tRNA ligase, mitochondrial isoform X4

  5. XM_063279090.1 → XP_063135160.1  valine--tRNA ligase, mitochondrial isoform X2

RNA

  1. XR_010060663.1 RNA Sequence

  2. XR_010060661.1 RNA Sequence

  3. XR_010060662.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MG21.1 GenPept UniProtKB/Swiss-Prot:Q6MG21

Gene LinkOut

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