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Zbtb22 zinc finger and BTB domain containing 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309630, updated on 28-Oct-2024

Summary

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Official Symbol
Zbtb22provided by RGD
Official Full Name
zinc finger and BTB domain containing 22provided by RGD
Primary source
RGD:1359627
See related
EnsemblRapid:ENSRNOG00000000476 AllianceGenome:RGD:1359627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bing1; Zfp297; Znf297
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZBTB22 (zinc finger and BTB domain containing 22). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 62.3), Heart (RPKM 60.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb22 in Genome Data Viewer
Location:
20p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4968215..4971734, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4966331..4969853, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5476345..5479900, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator like 2 Neighboring gene TAP binding protein Neighboring gene death-domain associated protein Neighboring gene AA926063gene Neighboring gene small integral membrane protein 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 22
Names
zinc finger protein 297

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009172.3 → NP_001009172.1  zinc finger and BTB domain-containing protein 22

    See identical proteins and their annotated locations for NP_001009172.1

    Status: VALIDATED

    Source sequence(s)
    BC095905
    UniProtKB/TrEMBL
    A0A8I6A8H9, A6JJI6, Q6MGC7
    Related
    ENSRNOP00000098206.1, ENSRNOT00000120565.2
    Conserved Domains (4) summary
    sd00017
    Location:485 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18210
    Location:36 → 147
    BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
    pfam00096
    Location:510 → 532
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:524 → 547
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4968215..4971734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256123.5 → XP_006256185.1  zinc finger and BTB domain-containing protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006256185.1

    UniProtKB/TrEMBL
    A0A8I6A8H9, A6JJI6, Q6MGC7
    Conserved Domains (4) summary
    sd00017
    Location:485 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18210
    Location:36 → 147
    BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
    pfam00096
    Location:510 → 532
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:524 → 547
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017601641.3 → XP_017457130.1  zinc finger and BTB domain-containing protein 22 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8H9, A6JJI6, Q6MGC7
    Conserved Domains (4) summary
    sd00017
    Location:485 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18210
    Location:36 → 147
    BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
    pfam00096
    Location:510 → 532
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:524 → 547
    zf-H2C2_2; Zinc-finger double domain

  3. XM_039098679.2 → XP_038954607.1  zinc finger and BTB domain-containing protein 22 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8H9, A6JJI6, Q6MGC7
    Conserved Domains (4) summary
    sd00017
    Location:485 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18210
    Location:36 → 147
    BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
    pfam00096
    Location:510 → 532
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:524 → 547
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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