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Taf11 TATA-box binding protein associated factor 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309638, updated on 17-Aug-2024

Summary

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Official Symbol
Taf11provided by RGD
Official Full Name
TATA-box binding protein associated factor 11provided by RGD
Primary source
RGD:1305626
See related
EnsemblRapid:ENSRNOG00000024601 AllianceGenome:RGD:1305626
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including TBP-class protein binding activity; nuclear receptor binding activity; and protein N-terminus binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly and positive regulation by host of viral transcription. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Orthologous to human TAF11 (TATA-box binding protein associated factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 54.1), Kidney (RPKM 48.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Taf11 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5957540..5965354, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5955774..5963593, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7476648..7484417, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483861 Neighboring gene small nuclear ribonucleoprotein polypeptide C Neighboring gene small nucleolar RNA SNORA26 Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene uncharacterized LOC102552617 Neighboring gene t-complex 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human TAF(II)28 interacts with the human T cell leukemia virus type I Tax transactivator and promotes its transcriptional activity. Caron C, et al. Proc Natl Acad Sci U S A, 1997 Apr 15. PMID 9108034, Free PMC Article
  2. The human transcription factor IID subunit human TATA-binding protein-associated factor 28 interacts in a ligand-reversible manner with the vitamin D(3) and thyroid hormone receptors. Mengus G, et al. J Biol Chem, 2000 Apr 7. PMID 10744685
  3. Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors. May M, et al. EMBO J, 1996 Jun 17. PMID 8670810, Free PMC Article
  4. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. Mengus G, et al. EMBO J, 1995 Apr 3. PMID 7729427, Free PMC Article
  5. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, et al. Biochimie, 2013 Apr. PMID 23146842

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105516

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear vitamin D receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 11
Names
TAF(II)28
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
TAFII-28
TAFII28
TATA box binding protein (TBP)-associated factor 11
TFIID subunit p30-beta
transcription initiation factor TFIID 28 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008350.1 → NP_001008351.1  transcription initiation factor TFIID subunit 11

    See identical proteins and their annotated locations for NP_001008351.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086421
    UniProtKB/Swiss-Prot
    Q5U1X0
    UniProtKB/TrEMBL
    A6JJP1
    Related
    ENSRNOP00000033634.2, ENSRNOT00000038195.4
    Conserved Domains (1) summary
    pfam04719
    Location:108 → 192
    TAFII28; hTAFII28-like protein conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    5957540..5965354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279121.1 → XP_063135191.1  transcription initiation factor TFIID subunit 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQE7
    Related
    ENSRNOP00000096221.1, ENSRNOT00000116514.2

  2. XM_063279122.1 → XP_063135192.1  transcription initiation factor TFIID subunit 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQE7

  3. XM_039098682.2 → XP_038954610.1  transcription initiation factor TFIID subunit 11 isoform X2

    Conserved Domains (1) summary
    cl02176
    Location:108 → 136
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  4. XM_063279120.1 → XP_063135190.1  transcription initiation factor TFIID subunit 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQE7

  5. XM_063279123.1 → XP_063135193.1  transcription initiation factor TFIID subunit 11 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U1X0.1 GenPept UniProtKB/Swiss-Prot:Q5U1X0

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