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Fance FA complementation group E [ Rattus norvegicus (Norway rat) ]

Gene ID: 309643, updated on 2-Nov-2024

Summary

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Official Symbol
Fanceprovided by RGD
Official Full Name
FA complementation group Eprovided by RGD
Primary source
RGD:1561045
See related
EnsemblRapid:ENSRNOG00000000504 AllianceGenome:RGD:1561045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561045
Summary
Predicted to be involved in interstrand cross-link repair. Predicted to be located in centrosome; chromatin; and nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group E. Orthologous to human FANCE (FA complementation group E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 60.2), Kidney (RPKM 59.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fance in Genome Data Viewer
Location:
20p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6371153..6388366)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6369416..6386631)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7888927..7906142)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene peroxisome proliferator-activated receptor delta Neighboring gene uncharacterized LOC120098961 Neighboring gene transfer RNA proline (anticodon AGG) 65 Neighboring gene ribosomal protein L10A Neighboring gene TEA domain transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model. Fu C, et al. PLoS One, 2016. PMID 26939056, Free PMC Article
  2. Isolation of a cDNA representing the Fanconi anemia complementation group E gene. de Winter JP, et al. Am J Hum Genet, 2000 Nov. PMID 11001585, Free PMC Article
  3. Regulation of Rev1 by the Fanconi anemia core complex. Kim H, et al. Nat Struct Mol Biol, 2012 Jan 22. PMID 22266823, Free PMC Article
  4. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Yan Z, et al. Mol Cell, 2010 Mar 26. PMID 20347428, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Fanconi anaemia nuclear complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Fanconi anemia group E protein
Names
Fanconi anemia, complementation group E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191718.1 → NP_001178647.1  Fanconi anemia group E protein

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    F1M286
    Related
    ENSRNOP00000006191.8, ENSRNOT00000006191.8
    Conserved Domains (1) summary
    cl12008
    Location:290 → 549
    FANCE_c-term; Fanconi anemia complementation group E protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    6371153..6388366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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