U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cfap410 cilia and flagella associated protein 410 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309681, updated on 2-Nov-2024

Summary

Official Symbol
Cfap410provided by RGD
Official Full Name
cilia and flagella associated protein 410provided by RGD
Primary source
RGD:1309594
See related
EnsemblRapid:ENSRNOG00000001215 AllianceGenome:RGD:1309594
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309594
Summary
Predicted to be involved in cytoskeleton organization and regulation of cell shape. Predicted to act upstream of or within cilium assembly and smoothened signaling pathway. Predicted to be located in several cellular components, including ciliary basal body; mitochondrion; and photoreceptor cell cilium. Human ortholog(s) of this gene implicated in axial spondylometaphyseal dysplasia. Orthologous to human CFAP410 (cilia and flagella associated protein 410). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 59.4), Brain (RPKM 49.7) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cfap410 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10687506..10694366, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10687863..10694736, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11417428..11424301, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene autoimmune regulator Neighboring gene phosphofructokinase, liver type Neighboring gene transient receptor potential cation channel, subfamily M, member 2 Neighboring gene Z6 small nucleolar RNA Neighboring gene Z6 small nucleolar RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC95110

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor cell cilium ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor connecting cilium ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cilia and flagella associated protein 410

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008351.1NP_001008352.1  cilia and flagella associated protein 410

    See identical proteins and their annotated locations for NP_001008352.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085944
    UniProtKB/TrEMBL
    A0A8I6G609, F7FCR2, Q5RKG5
    Related
    ENSRNOP00000045156.3, ENSRNOT00000049745.6
    Conserved Domains (3) summary
    sd00035
    Location:4263
    LRR_NTF; leucine-rich repeat [structural motif]
    NF033189
    Location:1204
    internalin_A; class 1 internalin InlA
    cd21340
    Location:40130
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    10687506..10694366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256252.4XP_006256314.1  cilia and flagella associated protein 410 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G609
    Conserved Domains (2) summary
    sd00035
    Location:425
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam12799
    Location:242
    LRR_4; Leucine Rich repeats (2 copies)