Itgb2 integrin subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgb2provided by RGD
Official Full Name: integrin subunit beta 2provided by RGD
Primary source: RGD:1305581
See related: EnsemblRapid:ENSRNOG00000001224 AllianceGenome:RGD:1305581
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd18
Summary: Contributes to cell adhesion molecule binding activity. Involved in several processes, including leukocyte migration involved in inflammatory response; positive regulation of NF-kappaB transcription factor activity; and positive regulation of nitric oxide biosynthetic process. Located in cell surface. Used to study nephritis and pneumonia. Biomarker of allergic rhinitis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 497.4), Thymus (RPKM 258.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (11061009..11097242, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (11061394..11097656, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (11777773..11815647, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beta2 integrin expression showed a 3-4-fold increase in the combined treatment group at all time points and kept increasing till day 56
Title: Modulation of Beta2 and Beta3 integrins in experimental colitis induced by iodoacetamide and enteropathogenic E. coli.
Freezing/thawing of PMNs can elicit an increase in PMN LFA-1 expression and trigger PMN-vascular endothelial cell adhesion.
Title: [The role of LFA-1 in the vascular endothelial cells injury mediated by frozen/thawed neutrophils].
Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil beta(2) integrin function.
Title: Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil β(2) integrin function.
TNF-alpha can promote expression of LFA-1 on surface of frozen/thawed polymorphonuclear lymphocytes and adhesion of PMN to vascular endothelial cells.
Title: [Role of TNF-alpha in vascular endothelial cells injury mediated by frozen/thawed PMN].
Our data demonstrated the upregulation of ICAM-1, LFA-1, and Mac-1 in the spinal cords of LPS intraspinal injected rats, and the location of ICAM-1 in microglia cells.
Title: Evaled expression of ICAM-1 and its ligands in the rat spinal cord following lipopolysaccharide intraspinal injection.
The expressions of CD18 and CD11b at 1 and 3 h after a 90-min trauma induced shock were significantly increased
Title: Effects of intestinal lymph on expression of neutrophil adhesion factors and lung injury after trauma-induced shock.
Blockade of CD18 in EPCs significantly inhibited their attachment capacity in vitro and reduced their recruitment to the ischemic myocardium in vivo by 95%
Title: Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium.
ICAM-1, LFA-1, and Mac-1 are upregulated in experimental acute pancreatitis of rats
Title: Expression and significance of ICAM-1 and its counter receptors LFA-1 and Mac-1 in experimental acute pancreatitis of rats.
the extracellular domain of CD18 molecules is cleaved in neutrophils in response to fluid shear stress.
Title: Regulation of CD18 expression on neutrophils in response to fluid shear stress.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgb2 (e-PCR), detects polymorphism
- UniSTS:143630

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ICAM-3 receptor activity	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
contributes_to cargo receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to cell adhesion molecule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables complement component C3b binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alphaL-beta2 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphaM-beta2 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphaX-beta2 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin beta-2

Names: CD18 leukocyte adhesion molecule; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit); macrophage antigen 1 (mac-1) beta subunit)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037780.2 → NP_001032869.2 integrin beta-2 precursor

See identical proteins and their annotated locations for NP_001032869.2

Status: VALIDATED

Source sequence(s)

BC085817

UniProtKB/TrEMBL

A0A9K3Y824, A6JK86, B2RYB8, F7F4S8

Related

ENSRNOP00000001639.5, ENSRNOT00000001639.8

Conserved Domains (3) summary

smart00187
Location:33 → 447

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:622 → 698

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:723 → 765

Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

11061009..11097242 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098729.2 → XP_038954657.1 integrin beta-2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y824, A6JK86, B2RYB8, F7F4S8

Related

ENSRNOP00000082439.1, ENSRNOT00000119404.2

Conserved Domains (3) summary

smart00187
Location:33 → 447

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:622 → 698

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:723 → 765

Integrin_b_cyt; Integrin beta cytoplasmic domain
XM_039098730.2 → XP_038954658.1 integrin beta-2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y824, A6JK86, B2RYB8, F7F4S8

Conserved Domains (3) summary

smart00187
Location:33 → 447

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:622 → 698

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:723 → 765

Integrin_b_cyt; Integrin beta cytoplasmic domain
XM_063279156.1 → XP_063135226.1 integrin beta-2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y824, B2RYB8, F7F4S8