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G9a - G9a

Enables histone-lysine N-methyltransferase activity. Involved in several processes, including ecdysone receptor-mediated signaling pathway; learning or memory; and positive regulation of histone H3-K9 dimethylation. Located in nucleus and polytene chromosome interband. Colocalizes with euchromatin. Is expressed in several structures, including central nervous system; embryonic/larval epidermis; embryonic/larval muscle system; gonad; and multidendritic neurons. Used to study Kleefstra syndrome 1 and viral infectious disease. Human ortholog(s) of this gene implicated in Kleefstra syndrome; Kleefstra syndrome 1; and idiopathic pulmonary fibrosis. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1) and EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Genes similar to G9a

NCBI Orthologs

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Species Gene Architecture aa