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Rhobtb1 Rho-related BTB domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309722, updated on 2-Nov-2024

Summary

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Symbol
Rhobtb1provided by RGD
Full Name
Rho-related BTB domain containing 1provided by RGD
Primary source
RGD:1306871
See related
EnsemblRapid:ENSRNOG00000000633 AllianceGenome:RGD:1306871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Orthologous to human RHOBTB1 (Rho related BTB domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 163.6), Heart (RPKM 82.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhobtb1 in Genome Data Viewer
Location:
20p11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (19326197..19455182, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (19327142..19456121, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (20638579..20715437, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 1 Neighboring gene uncharacterized LOC102554932 Neighboring gene uncharacterized LOC120098936 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC120098858

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1. Xiao J, et al. Exp Mol Med, 2017 Oct 20. PMID 29053138, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107622.2 → NP_001101092.1  rho-related BTB domain-containing protein 1

    See identical proteins and their annotated locations for NP_001101092.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Related
    ENSRNOP00000000784.6, ENSRNOT00000000784.8
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    19326197..19455182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098734.2 → XP_038954662.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_063279165.1 → XP_063135235.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6JKT8, D3ZD37

  3. XM_039098733.2 → XP_038954661.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  4. XM_039098737.2 → XP_038954665.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  5. XM_063279164.1 → XP_063135234.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6JKT8, D3ZD37

  6. XM_039098735.2 → XP_038954663.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  7. XM_039098736.2 → XP_038954664.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  8. XM_039098732.2 → XP_038954660.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  9. XM_039098739.2 → XP_038954667.1  rho-related BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATD4, A6JKT8, D3ZD37
    Conserved Domains (3) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18530
    Location:592 → 691
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:464 → 589
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  10. XM_039098741.2 → XP_038954669.1  rho-related BTB domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ATD4
    Conserved Domains (3) summary
    cd18530
    Location:503 → 602
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:375 → 500
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:10 → 118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  11. XM_039098743.2 → XP_038954671.1  rho-related BTB domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ATD4
    Conserved Domains (3) summary
    cd18530
    Location:472 → 571
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:344 → 469
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:1 → 87
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  12. XM_039098740.2 → XP_038954668.1  rho-related BTB domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JWZ1, A0A8I6ATD4
    Related
    ENSRNOP00000070070.2, ENSRNOT00000087085.3
    Conserved Domains (3) summary
    cd18530
    Location:534 → 633
    BACK_RHOBTB1; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1)
    cl38908
    Location:406 → 531
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:41 → 149
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
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