Sirt1 sirtuin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309757, updated on 2-Nov-2024

Summary

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Official Symbol: Sirt1provided by RGD
Official Full Name: sirtuin 1provided by RGD
Primary source: RGD:1308542
See related: EnsemblRapid:ENSRNOG00000051592 AllianceGenome:RGD:1308542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sir2
Summary: Enables NAD-dependent histone deacetylase activity and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in growth cone and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); cocaine dependence; impotence; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 148.7), Kidney (RPKM 142.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Sirt1 in Genome Data Viewer

Location:: 20p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (25305953..25328000)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (25307225..25329273)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (26831971..26851587, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS.
Title: ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS.
SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury.
Title: SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury.
Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial Necroptosis by Activation of RIPK1 Acetylation.
Title: Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial Necroptosis by Activation of RIPK1 Acetylation.
SIRT1-Mediated HMGB1 Deacetylation Suppresses Neutrophil Extracellular Traps Related to Blood-Brain Barrier Impairment After Cerebral Venous Thrombosis.
Title: SIRT1-Mediated HMGB1 Deacetylation Suppresses Neutrophil Extracellular Traps Related to Blood-Brain Barrier Impairment After Cerebral Venous Thrombosis.
BMAL1 alleviates myocardial damage in sepsis by activating SIRT1 signaling and promoting mitochondrial autophagy.
Title: BMAL1 alleviates myocardial damage in sepsis by activating SIRT1 signaling and promoting mitochondrial autophagy.
SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1.
Title: SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1.
PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition.
Title: PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition.
SIRT1 activation ameliorates rhesus monkey liver fibrosis by inhibiting the TGF-beta/smad signaling pathway.
Title: SIRT1 activation ameliorates rhesus monkey liver fibrosis by inhibiting the TGF-β/smad signaling pathway.
MiR-34a ameliorates arterial blood flow in rats with lower limb arteriosclerosis obliterans via Sirt1 signaling pathway.
Title: MiR-34a ameliorates arterial blood flow in rats with lower limb arteriosclerosis obliterans via Sirt1 signaling pathway.
MicroRNA-141-3p reduces pulmonary hypoxia/reoxygenation injury through suppression of Beclin-1-dependent autophagy.
Title: MicroRNA-141-3p reduces pulmonary hypoxia/reoxygenation injury through suppression of Beclin-1-dependent autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (385)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124528 (e-PCR)
- UniSTS:161350

RH140601 (e-PCR)
- UniSTS:222670

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables HLH domain binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone H3K14 deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone H3K9 deacetylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone H3K9 deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone H4K16 deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD-dependent histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone decrotonylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent histone decrotonylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables caspase binding	ISO Inferred from Sequence Orthology more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H3K deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables keratin filament binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	IBA Inferred from Biological aspect of Ancestor more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase B binding	IDA Inferred from Direct Assay more info	PubMed
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables protein lysine delactylase activity	ISO Inferred from Sequence Orthology more info
enables protein-propionyllysine depropionylase activity	IEA Inferred from Electronic Annotation more info
enables protein-propionyllysine depropionylase activity	ISO Inferred from Sequence Orthology more info
enables protein-propionyllysine depropionylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in DNA synthesis involved in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in UV-damage excision repair	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to starvation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to curcumin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to resveratrol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to rotenone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vitamin B3	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of nucleus location	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to testosterone stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of helicase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation from ovarian follicle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovulation from ovarian follicle	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MHC class II biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adipose tissue development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cAMP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulosa cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thyroid-stimulating hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deacetylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein depropionylation	IEA Inferred from Electronic Annotation more info
involved_in protein depropionylation	ISO Inferred from Sequence Orthology more info
involved_in protein depropionylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine dimer repair by nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine dimer repair by nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in rDNA heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid storage	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of peroxisome proliferator activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by glucose	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fluoride	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to kainic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to leptin	ISO Inferred from Sequence Orthology more info
involved_in response to mycotoxin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to resveratrol	IEP Inferred from Expression Pattern more info	PubMed
involved_in single strand break repair	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in stress-induced premature senescence	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in triglyceride mobilization	IEA Inferred from Electronic Annotation more info
involved_in triglyceride mobilization	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in white fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in white fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of chromatin silencing complex	ISO Inferred from Sequence Orthology more info
NOT located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of eNoSc complex	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IEA Inferred from Electronic Annotation more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in rDNA heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in rDNA heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-1

Names: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Sir2alpha; sirtuin 1 ((silent mating type information regulation 2, homolog) 1

NP_001359019.1

EC 2.3.1.286

NP_001401888.1

EC 2.3.1.286

XP_063135239.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372090.1 → NP_001359019.1 NAD-dependent protein deacetylase sirtuin-1 isoform 2

Status: VALIDATED

Source sequence(s)

CV104479, JACYVU010000324

UniProtKB/TrEMBL

A0A8I6B0Z5

Related

ENSRNOP00000094468.1, ENSRNOT00000119601.2

Conserved Domains (1) summary

cl00195
Location:12 → 186

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
NM_001414959.1 → NP_001401888.1 NAD-dependent protein deacetylase sirtuin-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I6A306

Related

ENSRNOP00000086140.1, ENSRNOT00000095567.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

25305953..25328000

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279169.1 → XP_063135239.1 NAD-dependent protein deacetylase sirtuin-1 isoform X1

UniProtKB/TrEMBL

A0A8I6B0Z5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107627.1: Suppressed sequence

Description

NM_001107627.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: SIRT1 (GeneID:423646).