U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 309812, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Rev3lprovided by RGD
Official Full Name
REV3 like, DNA directed polymerase zeta catalytic subunitprovided by RGD
Primary source
RGD:1307087
See related
EnsemblRapid:ENSRNOG00000000593 AllianceGenome:RGD:1307087
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via homologous recombination and error-prone translesion synthesis. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleolus. Predicted to be part of zeta DNA polymerase complex. Predicted to be active in nucleus. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 176.1), Uterus (RPKM 135.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rev3l in Genome Data Viewer
Location:
20q12
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (44686482..44844668)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43131841..43290102)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44803664..44961362)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098872 Neighboring gene uncharacterized LOC134483824 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene peptidylprolyl isomerase G, pseudogene 2 Neighboring gene major facilitator superfamily domain containing 4B1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two percent of patients suspected of having Angelman syndrome have TCF4 mutations. Takano K, et al. Clin Genet, 2010 Sep. PMID 20184619
  2. Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage. Van Sloun PP, et al. Mol Cell Biol, 2002 Apr. PMID 11884603, Free PMC Article
  3. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. Hara K, et al. J Biol Chem, 2010 Apr 16. PMID 20164194, Free PMC Article
  4. Regulation of ubiquitin ligase dynamics by the nucleolus. Mekhail K, et al. J Cell Biol, 2005 Aug 29. PMID 16129783, Free PMC Article
  5. DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ. Baranovskiy AG, et al. J Biol Chem, 2012 May 18. PMID 22465957, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zeta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA polymerase zeta catalytic subunit
Names
REV3-like, catalytic subunit of DNA polymerase zeta
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
NP_001077435.1
XP_006256586.1
XP_006256587.1
XP_063135243.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083966.1 → NP_001077435.1  DNA polymerase zeta catalytic subunit

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A6KIH1, F1M8G6
    Related
    ENSRNOP00000112650.1, ENSRNOT00000152978.1
    Conserved Domains (5) summary
    cd05778
    Location:2296 → 2534
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2560 → 3008
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam00136
    Location:2560 → 3007
    DNA_pol_B; DNA polymerase family B
    pfam14260
    Location:3044 → 3111
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:746 → 1132
    DUF4683; Domain of unknown function (DUF4683)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    44686482..44844668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279173.1 → XP_063135243.1  DNA polymerase zeta catalytic subunit isoform X3

    Related
    ENSRNOP00000104523.1, ENSRNOT00000131491.1

  2. XM_006256524.3 → XP_006256586.1  DNA polymerase zeta catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A6KIH1
    Related
    ENSRNOP00000054053.3, ENSRNOT00000057227.5
    Conserved Domains (5) summary
    cd05778
    Location:2297 → 2535
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2561 → 3009
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam00136
    Location:2561 → 3008
    DNA_pol_B; DNA polymerase family B
    pfam14260
    Location:3045 → 3112
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:747 → 1133
    DUF4683; Domain of unknown function (DUF4683)

  3. XM_006256525.4 → XP_006256587.1  DNA polymerase zeta catalytic subunit isoform X2

    UniProtKB/TrEMBL
    A6KIH1
    Conserved Domains (5) summary
    cd05778
    Location:2219 → 2457
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2483 → 2931
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam00136
    Location:2483 → 2930
    DNA_pol_B; DNA polymerase family B
    pfam14260
    Location:2967 → 3034
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:669 → 1055
    DUF4683; Domain of unknown function (DUF4683)

RNA

  1. XR_362259.3 RNA Sequence

  2. XR_005497269.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous