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Septin10 septin 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309891, updated on 10-Jul-2024

Summary

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Official Symbol
Septin10provided by RGD
Official Full Name
septin 10provided by RGD
Primary source
RGD:1359307
See related
EnsemblRapid:ENSRNOG00000049507 AllianceGenome:RGD:1359307
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sept10
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization and cytoskeleton-dependent cytokinesis. Predicted to be located in cytoskeleton. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Orthologous to human SEPTIN10 (septin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 184.1), Adrenal (RPKM 66.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Septin10 in Genome Data Viewer
Location:
20q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27644862..27737817, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27101764..27194997, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28722479..28814841, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 3 Neighboring gene leucine-rich repeat-containing protein 57-like Neighboring gene uncharacterized LOC134483910 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene small nuclear ribonucleoprotein D2-like Neighboring gene prolyl 4-hydroxylase subunit alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
septin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014033.1 → NP_001014055.1  septin-10

    See identical proteins and their annotated locations for NP_001014055.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087157
    UniProtKB/Swiss-Prot
    Q5PQK1
    UniProtKB/TrEMBL
    A0A0H2UI27
    Conserved Domains (3) summary
    cd01850
    Location:40 → 308
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:21 → 393
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl20817
    Location:337 → 393
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    27644862..27737817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256417.5 → XP_006256479.1  septin-10 isoform X3

    See identical proteins and their annotated locations for XP_006256479.1

    UniProtKB/TrEMBL
    A0A0H2UI27, A6K3U3
    Related
    ENSRNOP00000103161.1, ENSRNOT00000142196.1
    Conserved Domains (3) summary
    cd01850
    Location:36 → 304
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:17 → 389
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl20817
    Location:333 → 389
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_006256415.5 → XP_006256477.1  septin-10 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UI27
    Conserved Domains (3) summary
    cd01850
    Location:46 → 314
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:27 → 399
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl20817
    Location:343 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_017601667.3 → XP_017457156.1  septin-10 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UI27
    Related
    ENSRNOP00000073404.3, ENSRNOT00000086030.3

  4. XM_039098775.2 → XP_038954703.1  septin-10 isoform X5

    UniProtKB/TrEMBL
    A0A0H2UI27
    Related
    ENSRNOP00000091271.1, ENSRNOT00000112391.2
    Conserved Domains (2) summary
    cd01850
    Location:21 → 289
    CDC_Septin; CDC/Septin GTPase family
    pfam17380
    Location:227 → 370
    DUF5401; Family of unknown function (DUF5401)

  5. XM_039098777.2 → XP_038954705.1  septin-10 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K5F4
    Conserved Domains (2) summary
    cd01850
    Location:36 → 304
    CDC_Septin; CDC/Septin GTPase family
    pfam17380
    Location:242 → 385
    DUF5401; Family of unknown function (DUF5401)

  6. XM_006256418.5 → XP_006256480.1  septin-10 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K5F4
    Related
    ENSRNOP00000064265.4, ENSRNOT00000071663.4
    Conserved Domains (3) summary
    cd01850
    Location:46 → 314
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:27 → 399
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl20817
    Location:343 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  7. XM_063279185.1 → XP_063135255.1  septin-10 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K5F4

  8. XM_039098776.2 → XP_038954704.1  septin-10 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K5F4
    Conserved Domains (2) summary
    cd01850
    Location:40 → 308
    CDC_Septin; CDC/Septin GTPase family
    pfam17380
    Location:246 → 389
    DUF5401; Family of unknown function (DUF5401)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQK1.1 GenPept UniProtKB/Swiss-Prot:Q5PQK1

Gene LinkOut

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