U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rtn4ip1 reticulon 4 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309912, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Rtn4ip1provided by RGD
Official Full Name
reticulon 4 interacting protein 1provided by RGD
Primary source
RGD:1563384
See related
EnsemblRapid:ENSRNOG00000000279 AllianceGenome:RGD:1563384
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563384
Summary
Predicted to enable NADPH dehydrogenase (quinone) activity. Predicted to be involved in regulation of dendrite development and ubiquinone biosynthetic process. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 97.6), Muscle (RPKM 60.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rtn4ip1 in Genome Data Viewer
Location:
20q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (48964903..49004235)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (47382251..47422747)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48881124..48924921)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483830 Neighboring gene nuclear speckle splicing regulatory protein 1, pseudogene 1 Neighboring gene glutaminyl-tRNA amidotransferase subunit QRSL1 Neighboring gene crystallin beta-gamma domain containing 1 Neighboring gene heat shock cognate 71 kDa protein-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies. Angebault C, et al. Am J Hum Genet, 2015 Nov 5. PMID 26593267, Free PMC Article
  2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADPH dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
reticulon-4-interacting protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107644.3 → NP_001101114.1  reticulon-4-interacting protein 1, mitochondrial

    See identical proteins and their annotated locations for NP_001101114.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166465
    UniProtKB/TrEMBL
    A6K6W3, B2GUZ6, F7ESF4
    Related
    ENSRNOP00000109113.1, ENSRNOT00000132854.1
    Conserved Domains (2) summary
    cd08248
    Location:43 → 394
    RTN4I1; Human Reticulon 4 Interacting Protein 1
    COG0604
    Location:43 → 395
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    48964903..49004235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279188.1 → XP_063135258.1  reticulon-4-interacting protein 1, mitochondrial isoform X1

  2. XM_063279190.1 → XP_063135260.1  reticulon-4-interacting protein 1, mitochondrial isoform X3

  3. XM_063279189.1 → XP_063135259.1  reticulon-4-interacting protein 1, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools