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Arrdc3 arrestin domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309945, updated on 14-Nov-2024

Summary

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Symbol
Arrdc3provided by RGD
Full Name
arrestin domain containing 3provided by RGD
Primary source
RGD:1359478
See related
EnsemblRapid:ENSRNOG00000045649 AllianceGenome:RGD:1359478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00048
Summary
Predicted to enable beta-3 adrenergic receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; positive regulation of hippo signaling; and protein transport. Predicted to act upstream of or within several processes, including fat pad development; negative regulation of locomotion involved in locomotory behavior; and positive regulation of ubiquitin-protein transferase activity. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 774.4), Adrenal (RPKM 559.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arrdc3 in Genome Data Viewer
Location:
2q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (12873202..12885716)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (11137464..11149978)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (8732907..8745445)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene thymine-DNA glycosylase, pseudogene 1 Neighboring gene uncharacterized LOC120100652 Neighboring gene UBX domain protein 1, pseudogene Neighboring gene uncharacterized LOC120100653

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt signaling pathway. Zhang B, et al. Immunopharmacol Immunotoxicol, 2023 Apr. PMID 36154540
  2. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Patwari P, et al. Cell Metab, 2011 Nov 2. PMID 21982743, Free PMC Article
  3. Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. Shea FF, et al. PLoS One, 2012. PMID 23236378, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt signaling pathway.
    Title: ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt signaling pathway.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-3 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-3 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fat pad development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fat pad development ISO
Inferred from Sequence Orthology
more info
  
involved_in heat generation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of heat generation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of heat generation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of heat generation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skin development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skin development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within temperature homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arrestin domain-containing protein 3
Names
liver regeneration-related protein LRRG00048

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007797.2 → NP_001007798.1  arrestin domain-containing protein 3

    See identical proteins and their annotated locations for NP_001007798.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q6TXF1
    UniProtKB/TrEMBL
    A0A8L2QZ95, A6I4I1
    Related
    ENSRNOP00000078331.1, ENSRNOT00000106948.2
    Conserved Domains (2) summary
    smart01017
    Location:187 → 314
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:22 → 165
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. NR_178214.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    12873202..12885716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590815.3 → XP_017446304.1  arrestin domain-containing protein 3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TXF1.1 GenPept UniProtKB/Swiss-Prot:Q6TXF1

Gene LinkOut

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Chemical Information
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