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Ap3b1 adaptor related protein complex 3 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309969, updated on 2-Nov-2024

Summary

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Official Symbol
Ap3b1provided by RGD
Official Full Name
adaptor related protein complex 3 subunit beta 1provided by RGD
Primary source
RGD:1310256
See related
EnsemblRapid:ENSRNOG00000010624 AllianceGenome:RGD:1310256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP-dependent protein binding activity and protein phosphatase binding activity. Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Predicted to act upstream of with a positive effect on positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within with a negative effect on mRNA transcription by RNA polymerase II and regulation of catalytic activity. Predicted to act upstream of or within several processes, including establishment of protein localization to organelle; hemopoiesis; and vesicle organization. Predicted to be located in axon cytoplasm; clathrin-coated vesicle membrane; and mitochondrion. Predicted to be part of AP-3 adaptor complex and clathrin adaptor complex. Predicted to be active in microvesicle. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 2; interstitial lung disease; neutropenia; and pulmonary fibrosis. Orthologous to human AP3B1 (adaptor related protein complex 3 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 169.3), Thymus (RPKM 132.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap3b1 in Genome Data Viewer
Location:
2q12
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (27331241..27535683)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (25600069..25800937)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (24022815..24227522)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 2 Neighboring gene small nuclear ribonucleoprotein polypeptide N, pseudogene 5 Neighboring gene secretory carrier membrane protein 1 Neighboring gene uncharacterized LOC108349922 Neighboring gene tubulin folding cofactor A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease. Gochuico BR, et al. Mol Med, 2012 Feb 10. PMID 22009278, Free PMC Article
  2. Decreased hematopoietic progenitor cell mobilization in pearl mice. Vallejo MO, et al. Exp Hematol, 2013 Oct. PMID 23748140
  3. AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes. Huizing M, et al. Mol Biol Cell, 2001 Jul. PMID 11452004, Free PMC Article
  4. Defective organellar membrane protein trafficking in Ap3b1-deficient cells. Yang W, et al. J Cell Sci, 2000 Nov. PMID 11058094
  5. Genomic structure of the mouse Ap3b1 gene in normal and pearl mice. Feng L, et al. Genomics, 2000 Nov 1. PMID 11056055

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within antigen processing and presentation, exogenous lipid antigen via MHC class Ib ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of protein localization to mitochondrial membrane involved in mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within melanosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in melanosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within membrane organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet dense granule organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of NK T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein modification process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein targeting ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory system process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within single fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skin epidermis development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microvesicle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-3 complex subunit beta-1
Names
adaptor-related protein complex 3, beta 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429216.1 → NP_001416145.1  AP-3 complex subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6I4W7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    27331241..27535683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281703.1 → XP_063137773.1  AP-3 complex subunit beta-1 isoform X1

    Related
    ENSRNOP00000110034.1, ENSRNOT00000173506.1

  2. XM_063281704.1 → XP_063137774.1  AP-3 complex subunit beta-1 isoform X2

  3. XM_063281705.1 → XP_063137775.1  AP-3 complex subunit beta-1 isoform X3

  4. XM_063281706.1 → XP_063137776.1  AP-3 complex subunit beta-1 isoform X4

  5. XM_063281707.1 → XP_063137777.1  AP-3 complex subunit beta-1 isoform X4

  6. XM_063281708.1 → XP_063137778.1  AP-3 complex subunit beta-1 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107646.1: Suppressed sequence

    Description
    NM_001107646.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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