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Rad17 RAD17 checkpoint clamp loader component [ Rattus norvegicus (Norway rat) ]

Gene ID: 310034, updated on 17-Aug-2024

Summary

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Official Symbol
Rad17provided by RGD
Official Full Name
RAD17 checkpoint clamp loader componentprovided by RGD
Primary source
RGD:1309515
See related
EnsemblRapid:ENSRNOG00000018353 AllianceGenome:RGD:1309515
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including DNA repair; mitotic DNA integrity checkpoint signaling; and negative regulation of DNA replication. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Rad17 RFC-like complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 104.8), Testes (RPKM 94.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33498335..33528614, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31764260..31794542, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30634353..30664618, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene bolA-like 1-like Neighboring gene uncharacterized LOC102557393 Neighboring gene MARVEL domain containing 2 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin-dependent kinase 7 Neighboring gene KtI12 chromatin associated, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. Budzowska M, et al. EMBO J, 2004 Sep 1. PMID 15297881, Free PMC Article
  2. HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. Chang MS, et al. J Biol Chem, 1999 Dec 17. PMID 10593953
  3. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. Tsao CC, et al. EMBO J, 2004 Nov 24. PMID 15538388, Free PMC Article
  4. MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Wang Y, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14657349, Free PMC Article
  5. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Herbig U, et al. Mol Cell, 2004 May 21. PMID 15149599

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin-protein adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to site of double-strand break IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Rad17 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell cycle checkpoint protein RAD17
Names
RAD17 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024778.1 → NP_001019949.1  cell cycle checkpoint protein RAD17

    See identical proteins and their annotated locations for NP_001019949.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098057
    UniProtKB/TrEMBL
    Q4V7A2
    Related
    ENSRNOP00000024801.4, ENSRNOT00000024801.6
    Conserved Domains (2) summary
    TIGR00602
    Location:13 → 651
    rad24; checkpoint protein rad24
    pfam13238
    Location:133 → 253
    AAA_18; AAA domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    33498335..33528614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231848.4 → XP_006231910.1  cell cycle checkpoint protein RAD17 isoform X1

    UniProtKB/TrEMBL
    E9PTL1
    Conserved Domains (2) summary
    TIGR00602
    Location:13 → 651
    rad24; checkpoint protein rad24
    pfam13238
    Location:133 → 253
    AAA_18; AAA domain

  2. XM_039102173.2 → XP_038958101.1  cell cycle checkpoint protein RAD17 isoform X3

    Conserved Domains (1) summary
    TIGR00602
    Location:1 → 442
    rad24; checkpoint protein rad24

  3. XM_063281719.1 → XP_063137789.1  cell cycle checkpoint protein RAD17 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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