U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Drosha drosha ribonuclease III [ Rattus norvegicus (Norway rat) ]

Gene ID: 310159, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Droshaprovided by RGD
Official Full Name
drosha ribonuclease IIIprovided by RGD
Primary source
RGD:1307626
See related
EnsemblRapid:ENSRNOG00000013451 AllianceGenome:RGD:1307626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rn3; Etohi2; Rnasen; RGD1307626
Summary
Predicted to enable several functions, including DEAD/H-box RNA helicase binding activity; R-SMAD binding activity; and RNA binding activity. Predicted to be involved in defense response to bacterium and regulation of gene expression. Predicted to act upstream of or within several processes, including ncRNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Predicted to be located in cytosol; nucleoplasm; and postsynaptic density. Predicted to be part of microprocessor complex. Predicted to be active in nucleus. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 83.3), Kidney (RPKM 65.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Drosha in Genome Data Viewer
Location:
2q16
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (63591885..63703688)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61864886..61976688)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62887267..63000307)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909396 Neighboring gene similar to human chromosome 5 open reading frame 22 Neighboring gene uncharacterized LOC103695100 Neighboring gene cadherin 6 Neighboring gene 60S ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of putative rat ribonuclease III by differential display: a novel rat mRNA expressed in a circadian manner in the rat suprachiasmatic nucleus. Bhogal RK, et al. Brain Res Mol Brain Res, 2004 Nov 24. PMID 15530651
  2. The nuclear RNase III Drosha initiates microRNA processing. Lee Y, et al. Nature, 2003 Sep 25. PMID 14508493
  3. The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II. Pidíková P, et al. Gen Physiol Biophys, 2022 Sep. PMID 36222340
  4. Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall. Torrent M, et al. FEBS J, 2010 Apr. PMID 20180804
  5. The widespread regulation of microRNA biogenesis, function and decay. Krol J, et al. Nat Rev Genet, 2010 Sep. PMID 20661255

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
    Title: The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
  
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease III activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of microprocessor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of microprocessor complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribonuclease 3
Names
drosha, ribonuclease type III
ethanol induced 2
ribonuclease III, nuclear
ribonuclease type III, nuclear
NP_001101125.2
XP_006232112.2
XP_038958133.1
XP_038958134.1
XP_038958135.1
XP_063137814.1
XP_063137815.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107655.2 → NP_001101125.2  ribonuclease 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5Y0A2, E9PTR3
    Related
    ENSRNOP00000076463.2, ENSRNOT00000098160.2
    Conserved Domains (3) summary
    PRK00102
    Location:1104 → 1332
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:958 → 1078
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01622
    Location:212 → 274
    SF-CC1; splicing factor, CC1-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    63591885..63703688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232050.5 → XP_006232112.2  ribonuclease 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y0A2
    Conserved Domains (3) summary
    PRK00102
    Location:1096 → 1324
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:950 → 1070
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01622
    Location:212 → 274
    SF-CC1; splicing factor, CC1-like family

  2. XM_063281745.1 → XP_063137815.1  ribonuclease 3 isoform X3

  3. XM_039102206.1 → XP_038958134.1  ribonuclease 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A2, E9PTR3
    Related
    ENSRNOP00000050633.5, ENSRNOT00000048026.8
    Conserved Domains (3) summary
    PRK00102
    Location:1104 → 1332
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:958 → 1078
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01622
    Location:212 → 274
    SF-CC1; splicing factor, CC1-like family

  4. XM_039102207.1 → XP_038958135.1  ribonuclease 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A2, E9PTR3
    Conserved Domains (3) summary
    PRK00102
    Location:1104 → 1332
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:958 → 1078
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01622
    Location:212 → 274
    SF-CC1; splicing factor, CC1-like family

  5. XM_063281744.1 → XP_063137814.1  ribonuclease 3 isoform X2

  6. XM_039102205.1 → XP_038958133.1  ribonuclease 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0A2, E9PTR3
    Conserved Domains (3) summary
    PRK00102
    Location:1104 → 1332
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:958 → 1078
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01622
    Location:212 → 274
    SF-CC1; splicing factor, CC1-like family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools