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Dcun1d1 defective in cullin neddylation 1 domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310324, updated on 10-Jul-2024

Summary

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Symbol
Dcun1d1provided by RGD
Full Name
defective in cullin neddylation 1 domain containing 1provided by RGD
Primary source
RGD:1309668
See related
EnsemblRapid:ENSRNOG00000012734 AllianceGenome:RGD:1309668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tes3
Summary
Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; positive regulation of ubiquitin-protein transferase activity; and protein neddylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Orthologous to human DCUN1D1 (defective in cullin neddylation 1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 184.6), Spleen (RPKM 133.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dcun1d1 in Genome Data Viewer
Location:
2q25
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (120649445..120700879, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (118721275..118772606, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (122476173..122527153, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1158 Neighboring gene ATPase phospholipid transporting 11B (putative) Neighboring gene uncharacterized LOC134485899 Neighboring gene methylcrotonyl-CoA carboxylase subunit 1 Neighboring gene coiled-coil domain containing 144B Neighboring gene small ribosomal subunit protein uS13-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. Kim AY, et al. J Biol Chem, 2008 Nov 28. PMID 18826954, Free PMC Article
  2. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Scott DC, et al. Nat Chem Biol, 2017 Aug. PMID 28581483, Free PMC Article
  3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DCN1-like protein 1
Names
DCN1, defective in cullin neddylation 1, domain containing 1
DCN1-like protein 1-like
testis derived transcript 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395100.1 → NP_001382029.1  DCN1-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K8D6, A0A8I6AI94
    Related
    ENSRNOP00000092738.1, ENSRNOT00000111905.2
    Conserved Domains (1) summary
    cl21463
    Location:1 → 51
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    120649445..120700879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232261.5 → XP_006232323.1  DCN1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006232323.1

    UniProtKB/TrEMBL
    A0A8I5ZYZ4, A0A8I6ADB9
    Related
    ENSRNOP00000090810.1, ENSRNOT00000109045.2
    Conserved Domains (2) summary
    pfam03556
    Location:150 → 261
    Cullin_binding; Cullin binding
    cl21463
    Location:15 → 65
    UBA_like_SF; UBA domain-like superfamily

  2. XM_063281774.1 → XP_063137844.1  DCN1-like protein 1 isoform X3

    UniProtKB/TrEMBL
    D3ZRV0

  3. XM_006232262.5 → XP_006232324.1  DCN1-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8D6, A0A8I5Y621
    Related
    ENSRNOP00000076537.1, ENSRNOT00000104963.2
    Conserved Domains (2) summary
    pfam03556
    Location:141 → 252
    Cullin_binding; Cullin binding
    cl21463
    Location:6 → 56
    UBA_like_SF; UBA domain-like superfamily

  4. XM_063281773.1 → XP_063137843.1  DCN1-like protein 1 isoform X3

    UniProtKB/TrEMBL
    D3ZRV0

  5. XM_039102240.2 → XP_038958168.1  DCN1-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A6IHV8
    Conserved Domains (2) summary
    pfam03556
    Location:150 → 189
    Cullin_binding; Cullin binding
    cl21463
    Location:15 → 65
    UBA_like_SF; UBA domain-like superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107668.1: Suppressed sequence

    Description
    NM_001107668.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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