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Nim1k NIM1 serine/threonine protein kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 310376, updated on 10-Jul-2024

Summary

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Official Symbol
Nim1kprovided by RGD
Official Full Name
NIM1 serine/threonine protein kinaseprovided by RGD
Primary source
RGD:1308116
See related
EnsemblRapid:ENSRNOG00000016353 AllianceGenome:RGD:1308116
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nim1; RGD1308116
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in cellular response to glucose starvation; intracellular signal transduction; and protein phosphorylation. Orthologous to human NIM1K (NIM1 serine/threonine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 30.9), Liver (RPKM 11.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nim1k in Genome Data Viewer
Location:
2q15
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (53403467..53451248, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51670764..51714782, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52448746..52494137, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547360 Neighboring gene C-C motif chemokine ligand 28 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 1 Neighboring gene uncharacterized LOC134485849 Neighboring gene zinc finger protein 131 Neighboring gene RNA, U6 small nuclear 446

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. Jaleel M, et al. FEBS Lett, 2005 Feb 28. PMID 15733851
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase NIM1
XP_006232044.1
XP_038959451.1
XP_063138911.1
XP_063138912.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    53403467..53451248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231982.5 → XP_006232044.1  serine/threonine-protein kinase NIM1 isoform X1

    See identical proteins and their annotated locations for XP_006232044.1

    UniProtKB/TrEMBL
    D4A9H8
    Conserved Domains (1) summary
    cd14075
    Location:71 → 325
    STKc_NIM1; Catalytic domain of the Serine/Threonine Kinase, NIM1

  2. XM_039103523.2 → XP_038959451.1  serine/threonine-protein kinase NIM1 isoform X1

    UniProtKB/TrEMBL
    D4A9H8
    Conserved Domains (1) summary
    cd14075
    Location:71 → 325
    STKc_NIM1; Catalytic domain of the Serine/Threonine Kinase, NIM1

  3. XM_063282842.1 → XP_063138912.1  serine/threonine-protein kinase NIM1 isoform X2

    UniProtKB/TrEMBL
    A6I5X0

  4. XM_063282841.1 → XP_063138911.1  serine/threonine-protein kinase NIM1 isoform X1

    UniProtKB/TrEMBL
    D4A9H8
    Related
    ENSRNOP00000021964.3, ENSRNOT00000021964.7
Nucleotide Protein Strain
Heading Accession and Version

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