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Plch1 phospholipase C, eta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310463, updated on 10-Jul-2024

Summary

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Official Symbol
Plch1provided by RGD
Official Full Name
phospholipase C, eta 1provided by RGD
Primary source
RGD:1561991
See related
EnsemblRapid:ENSRNOG00000009955 AllianceGenome:RGD:1561991
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plcl3; RGD1561991
Summary
Predicted to enable calcium-dependent phospholipase C activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and membrane. Orthologous to human PLCH1 (phospholipase C eta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 34.1), Brain (RPKM 28.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plch1 in Genome Data Viewer
Location:
2q31
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (150298547..150514120, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (148148908..148363616, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (154256382..154468166, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene fission, mitochondrial 1, pseudogene 1 Neighboring gene similar to human chromosome 3 open reading frame 33 Neighboring gene solute carrier family 33 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Hwang JI, et al. Biochem J, 2005 Jul 1. PMID 15702972, Free PMC Article
  2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Names
phospholipase C-like 3
NP_001178636.1
XP_038958212.1
XP_063137859.1
XP_063137860.1
XP_063137861.1
XP_063137862.1
XP_063137863.1
XP_063137864.1
XP_063137865.1
XP_063137866.1
XP_063137867.1
XP_063137868.1
XP_063137869.1
XP_063137870.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191707.1 → NP_001178636.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A096MJ91, D4A4H0
    Related
    ENSRNOP00000068040.3, ENSRNOT00000076326.3
    Conserved Domains (6) summary
    cd00275
    Location:713 → 837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280 → 683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:128 → 194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209 → 280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129 → 190
    EF-hand_7; EF-hand domain pair
    cl17171
    Location:4 → 110
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    150298547..150514120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281791.1 → XP_063137861.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    UniProtKB/TrEMBL
    D4A4H0

  2. XM_063281797.1 → XP_063137867.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

    UniProtKB/TrEMBL
    D4A4H0

  3. XM_063281796.1 → XP_063137866.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

    UniProtKB/TrEMBL
    D4A4H0

  4. XM_063281792.1 → XP_063137862.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

    UniProtKB/TrEMBL
    D4A4H0

  5. XM_063281795.1 → XP_063137865.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    UniProtKB/TrEMBL
    D4A4H0

  6. XM_063281793.1 → XP_063137863.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

    UniProtKB/TrEMBL
    D4A4H0

  7. XM_063281789.1 → XP_063137859.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    UniProtKB/TrEMBL
    D4A4H0

  8. XM_063281790.1 → XP_063137860.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    UniProtKB/TrEMBL
    D4A4H0

  9. XM_063281794.1 → XP_063137864.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

    UniProtKB/TrEMBL
    A0A096MJW8

  10. XM_039102284.2 → XP_038958212.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X11

    Conserved Domains (1) summary
    cd00275
    Location:10 → 99
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

  11. XM_063281799.1 → XP_063137869.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

    UniProtKB/TrEMBL
    A0A096MJW5

  12. XM_063281798.1 → XP_063137868.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

    UniProtKB/TrEMBL
    A0A096MJW5

  13. XM_063281800.1 → XP_063137870.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X10

    UniProtKB/TrEMBL
    A0A096MJW5
    Related
    ENSRNOP00000068291.3, ENSRNOT00000076165.4
Nucleotide Protein Strain
Heading Accession and Version

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