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Tiparp TCDD-inducible poly(ADP-ribose) polymerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 310467, updated on 18-Sep-2024

Summary

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Official Symbol
Tiparpprovided by RGD
Official Full Name
TCDD-inducible poly(ADP-ribose) polymeraseprovided by RGD
Primary source
RGD:1306171
See related
EnsemblRapid:ENSRNOG00000011238 AllianceGenome:RGD:1306171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RM1
Summary
Predicted to enable NAD+ ADP-ribosyltransferase activity; cis-regulatory region sequence-specific DNA binding activity; and protein ADP-ribosylase activity. Involved in response to 2,3,7,8-tetrachlorodibenzodioxine. Predicted to be located in nucleus. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 150.5), Lung (RPKM 117.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tiparp in Genome Data Viewer
Location:
2q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (152063769..152090414)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (149753682..149780327)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (157316293..157342979)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene signal sequence receptor subunit 3 Neighboring gene uncharacterized LOC102554278 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L36A, pseudogene 11 Neighboring gene uncharacterized LOC134485623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TCDD dysregulation of 13 AHR-target genes in rat liver. Watson JD, et al. Toxicol Appl Pharmacol, 2014 Feb 1. PMID 24355419
  2. Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity. Gomez A, et al. Biochem J, 2018 Dec 11. PMID 30373764, Free PMC Article
  3. TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Ma Q, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716501
  4. Identification and cataloging of genes induced by long-lasting long-term potentiation in awake rats. Matsuo R, et al. J Neurochem, 2000 Jun. PMID 10820183
  5. The PDGF signaling pathway controls multiple steroid-producing lineages. Schmahl J, et al. Genes Dev, 2008 Dec 1. PMID 19056881, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein-cysteine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within androgen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within face morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within female gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in response to 2,3,7,8-tetrachlorodibenzodioxine IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within smooth muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase TIPARP
NP_001101149.2
XP_038958213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107679.3 → NP_001101149.2  protein mono-ADP-ribosyltransferase TIPARP

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6GA83, A6J5J7, D3ZMH5
    Related
    ENSRNOP00000015387.3, ENSRNOT00000015387.8
    Conserved Domains (2) summary
    cd01439
    Location:529 → 648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam02825
    Location:348 → 401
    WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    152063769..152090414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102285.2 → XP_038958213.1  protein mono-ADP-ribosyltransferase TIPARP isoform X1

    UniProtKB/TrEMBL
    A0A8I6GA83, A6J5J7, D3ZMH5
    Conserved Domains (2) summary
    cd01439
    Location:529 → 648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam02825
    Location:348 → 401
    WWE; WWE domain
Nucleotide Protein Strain
Heading Accession and Version

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