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Nmd3 NMD3 ribosome export adaptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 310512, updated on 2-Nov-2024

Summary

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Official Symbol
Nmd3provided by RGD
Official Full Name
NMD3 ribosome export adaptorprovided by RGD
Primary source
RGD:1308468
See related
EnsemblRapid:ENSRNOG00000009310 AllianceGenome:RGD:1308468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308468
Summary
Predicted to enable protein-macromolecule adaptor activity and ribosomal large subunit binding activity. Predicted to be involved in positive regulation of RNA biosynthetic process; positive regulation of protein localization to nucleolus; and ribosomal large subunit export from nucleus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human NMD3 (NMD3 ribosome export adaptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 232.8), Thymus (RPKM 159.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nmd3 in Genome Data Viewer
Location:
2q32
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (156285773..156348394)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (154012973..154038466)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (166402838..166428331)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphoserine aminotransferase 1, pseudogene 1 Neighboring gene RB binding protein 4, chromatin remodeling factor like 1 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 13 Neighboring gene serine palmitoyltransferase, small subunit B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Maturation of eukaryotic ribosomes: acquisition of functionality. Panse VG, et al. Trends Biochem Sci, 2010 May. PMID 20137954, Free PMC Article
  2. Nuclear export and cytoplasmic maturation of ribosomal subunits. Zemp I, et al. FEBS Lett, 2007 Jun 19. PMID 17509569
  3. Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway. Thomas F, et al. J Cell Sci, 2003 Jun 15. PMID 12724356
  4. CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus and affect rRNA synthesis. Bai B, et al. Nucleus, 2013 Jul-Aug. PMID 23782956, Free PMC Article
  5. Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates. Trotta CR, et al. EMBO J, 2003 Jun 2. PMID 12773398, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of RNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
60S ribosomal export protein NMD3
Names
NMD3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107682.2 → NP_001101152.1  60S ribosomal export protein NMD3

    See identical proteins and their annotated locations for NP_001101152.1

    Status: VALIDATED

    Source sequence(s)
    BC161998
    UniProtKB/TrEMBL
    A0A9K3Y797, A6J5N6, B1WC44, F7ERL4
    Related
    ENSRNOP00000012417.8, ENSRNOT00000012417.9
    Conserved Domains (1) summary
    pfam04981
    Location:17 → 246
    NMD3; NMD3 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    156285773..156348394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281803.1 → XP_063137873.1  60S ribosomal export protein NMD3 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y797, B1WC44, F7ERL4

  2. XM_063281802.1 → XP_063137872.1  60S ribosomal export protein NMD3 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y797, B1WC44, F7ERL4

  3. XM_039102292.2 → XP_038958220.1  60S ribosomal export protein NMD3 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y797, A6J5N6, B1WC44, F7ERL4
    Conserved Domains (1) summary
    pfam04981
    Location:17 → 246
    NMD3; NMD3 family

  4. XM_039102293.2 → XP_038958221.1  60S ribosomal export protein NMD3 isoform X3

    Conserved Domains (1) summary
    pfam04981
    Location:1 → 126
    NMD3; NMD3 family

  5. XM_063281804.1 → XP_063137874.1  60S ribosomal export protein NMD3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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