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Crtc2 CREB regulated transcription coactivator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310615, updated on 2-Nov-2024

Summary

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Official Symbol
Crtc2provided by RGD
Official Full Name
CREB regulated transcription coactivator 2provided by RGD
Primary source
RGD:1308903
See related
EnsemblRapid:ENSRNOG00000056337 AllianceGenome:RGD:1308903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Torc2; RGD1308903
Summary
Enables chromatin binding activity. Predicted to be involved in several processes, including cellular response to cAMP; gluconeogenesis; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Used to study type 2 diabetes mellitus. Orthologous to human CRTC2 (CREB regulated transcription coactivator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 54.4), Thymus (RPKM 46.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Crtc2 in Genome Data Viewer
Location:
2q34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178007233..178017397)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175709603..175719768)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189615928..189625646)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene solute carrier family 39 member 1 Neighboring gene DENN domain containing 4B Neighboring gene uncharacterized LOC102551157 Neighboring gene GATA zinc finger domain containing 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure. Highland JA, et al. Am J Physiol Cell Physiol, 2014 Oct 1. PMID 25080490, Free PMC Article
  2. Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis. Yoon YS, et al. Exp Mol Med, 2009 Aug 31. PMID 19381067, Free PMC Article
  3. Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Saberi M, et al. Am J Physiol Endocrinol Metab, 2009 Nov. PMID 19706791, Free PMC Article
  4. Temporal effect of adrenocorticotrophic hormone on adrenal glucocorticoid steroidogenesis: involvement of the transducer of regulated cyclic AMP-response element-binding protein activity. Spiga F, et al. J Neuroendocrinol, 2011 Feb. PMID 21083631, Free PMC Article
  5. CRTC2 and Nedd4 ligase involvement in FSH and TGFβ1 upregulation of connexin43 gap junction. Fang WL, et al. J Mol Endocrinol, 2015 Dec. PMID 26508620

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRTC2 and Nedd4 ligase involvement in FSH and TGFbeta1 upregulation of connexin43 gap junction
    Title: CRTC2 and Nedd4 ligase involvement in FSH and TGFβ1 upregulation of connexin43 gap junction.
  2. Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization.
    Title: The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte.
  3. Berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2 signaling pathway.
    Title: Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.
  4. These data suggest mTORC2 phosphorylation of Akt is a key mediator of H2S-induced cardioprotection in I/R.
    Title: mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection.
  5. Suggest that CRTC2 participates in CREB-dependent photic entrainment of suprachiasmatic nucleus function.
    Title: CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.
  6. CRTC2 inhibition resulted in reduced expression of several glucagon-induced pyridoxal 5'-phosphate-dependent enzymes that convert amino acids to gluconeogenic intermediates
    Title: cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.
  7. CRTC2 and calcineurin are critical signaling mediators in FSH and TGFbeta1-stimulated steroidogenesis in ovarian granulosa cells.
    Title: CREB coactivator CRTC2/TORC2 and its regulator calcineurin crucially mediate follicle-stimulating hormone and transforming growth factor β1 upregulation of steroidogenesis.
  8. The differential distribution patterns are consistent with complex roles for TORC1, -2, and -3 isoforms in diverse brain structures.
    Title: The distribution of messenger RNAs encoding the three isoforms of the transducer of regulated cAMP responsive element binding protein activity in the rat forebrain.
  9. Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling
    Title: Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling.
  10. TORC2 translocates to the nucleus of hypothalamic CRH neurones and interacts with the CRH promoter in conjunction with the activation of CRH transcription during restraint stress.
    Title: Stress induces parallel changes in corticotrophin-releasing hormone (CRH) Transcription and nuclear translocation of transducer of regulated cAMP response element-binding activity 2 in hypothalamic CRH neurones.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP response element binding protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP response element binding protein binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of CREB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
CREB-regulated transcription coactivator 2
Names
TORC-2
transducer of CREB protein 2
transducer of regulated cAMP response element-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033895.2 → NP_001029067.1  CREB-regulated transcription coactivator 2

    See identical proteins and their annotated locations for NP_001029067.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q3LRZ1
    UniProtKB/TrEMBL
    A0A8L2R0S0, B4F7E3
    Conserved Domains (3) summary
    pfam12884
    Location:18 → 72
    TORC_N; Transducer of regulated CREB activity, N-terminus
    pfam12885
    Location:168 → 316
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:613 → 690
    TORC_C; Transducer of regulated CREB activity, C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    178007233..178017397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281829.1 → XP_063137899.1  CREB-regulated transcription coactivator 2 isoform X5

  2. XM_063281828.1 → XP_063137898.1  CREB-regulated transcription coactivator 2 isoform X4

  3. XM_063281825.1 → XP_063137895.1  CREB-regulated transcription coactivator 2 isoform X1

  4. XM_063281826.1 → XP_063137896.1  CREB-regulated transcription coactivator 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3LRZ1
    UniProtKB/TrEMBL
    B4F7E3
    Related
    ENSRNOP00000068813.2, ENSRNOT00000092144.3

  5. XM_063281827.1 → XP_063137897.1  CREB-regulated transcription coactivator 2 isoform X3

RNA

  1. XR_010063607.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3LRZ1.1 GenPept UniProtKB/Swiss-Prot:Q3LRZ1

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