U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tnfaip8l2 TNF alpha induced protein 8 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310663, updated on 2-Nov-2024

Summary

Official Symbol
Tnfaip8l2provided by RGD
Official Full Name
TNF alpha induced protein 8 like 2provided by RGD
Primary source
RGD:1310519
See related
EnsemblRapid:ENSRNOG00000021100 AllianceGenome:RGD:1310519
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310519
Summary
Predicted to be involved in negative regulation of T cell activation and negative regulation of inflammatory response. Predicted to be located in lysosome and nucleus. Predicted to be active in cytoplasm. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 102.1), Thymus (RPKM 77.1) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tnfaip8l2 in Genome Data Viewer
Location:
2q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185399442..185415798, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182710433..182726724, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196309789..196329495, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tropomodulin 4 Neighboring gene sodium channel modifier 1 Neighboring gene LysM domain containing 1 Neighboring gene uncharacterized LOC120100877 Neighboring gene semaphorin 6C Neighboring gene GA binding protein transcription factor subunit beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 2
Names
TIPE2
TNF alpha-induced protein 8-like protein 2
TNFAIP8-like protein 2
tumor necrosis factor, alpha-induced protein 8-like 2
tumor necrosis factor, alpha-induced protein 8-like protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014039.1NP_001014061.1  tumor necrosis factor alpha-induced protein 8-like protein 2

    See identical proteins and their annotated locations for NP_001014061.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079019
    UniProtKB/Swiss-Prot
    Q6AYJ8
    UniProtKB/TrEMBL
    A6K2V2
    Related
    ENSRNOP00000028642.3, ENSRNOT00000028642.6
    Conserved Domains (1) summary
    pfam05527
    Location:5181
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185399442..185415798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590897.3XP_017446386.1  tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1

    Related
    ENSRNOP00000110113.1, ENSRNOT00000125109.1