U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cers2 ceramide synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310667, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cers2provided by RGD
Official Full Name
ceramide synthase 2provided by RGD
Primary source
RGD:1310059
See related
EnsemblRapid:ENSRNOG00000021138 AllianceGenome:RGD:1310059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lass2
Summary
Predicted to enable sphingosine N-acyltransferase activity. Involved in several processes, including negative regulation of Schwann cell migration; negative regulation of Schwann cell proliferation involved in axon regeneration; and negative regulation of axon regeneration. Predicted to be located in endoplasmic reticulum. Biomarker of sciatic neuropathy. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 637.0), Lung (RPKM 320.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cers2 in Genome Data Viewer
Location:
2q34
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185579511..185587789)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182890527..182898805)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196487656..196495930)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485650

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury. Yu B, et al. J Cell Sci, 2012 Jun 1. PMID 22393241
  2. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. Laviad EL, et al. J Biol Chem, 2008 Feb 29. PMID 18165233
  3. Enriched Environment Enhances the Myelin Regulatory Factor by mTOR Signaling and Protects the Myelin Membrane Against Oxidative Damage in Rats Exposed to Chronic Immobilization Stress. Thamizhoviya G, et al. Neurochem Res, 2021 Dec. PMID 34449011
  4. Eleven residues determine the acyl chain specificity of ceramide synthases. Tidhar R, et al. J Biol Chem, 2018 Jun 22. PMID 29632068, Free PMC Article
  5. Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis. Yamashita-Sugahara Y, et al. J Biol Chem, 2013 Feb 15. PMID 23275342, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sciatic nerve injury promotes Schwann cell proliferation and migration through the regulation of miR-221/222 by targeting LASS2
    Title: miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC124761

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Schwann cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Schwann cell proliferation involved in axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ceramide synthase 2
Names
LAG1 homolog, ceramide synthase 2
NP_001028872.2
XP_006232949.1
XP_006232950.1
XP_038958282.1
XP_038958283.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033700.2 → NP_001028872.2  ceramide synthase 2

    See identical proteins and their annotated locations for NP_001028872.2

    Status: VALIDATED

    Source sequence(s)
    BC101876, BI284504, CF110567, CK365108
    UniProtKB/TrEMBL
    A6K2Y5, G3V8V4, Q3T1K1
    Related
    ENSRNOP00000028699.2, ENSRNOT00000028699.6
    Conserved Domains (2) summary
    smart00724
    Location:131 → 332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71 → 128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185579511..185587789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232888.4 → XP_006232950.1  ceramide synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006232950.1

    UniProtKB/TrEMBL
    A6K2Y5, G3V8V4, Q3T1K1
    Conserved Domains (2) summary
    smart00724
    Location:131 → 332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71 → 128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. XM_039102355.2 → XP_038958283.1  ceramide synthase 2 isoform X1

    UniProtKB/TrEMBL
    A6K2Y5, G3V8V4, Q3T1K1
    Conserved Domains (2) summary
    smart00724
    Location:131 → 332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71 → 128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  3. XM_039102354.2 → XP_038958282.1  ceramide synthase 2 isoform X1

    UniProtKB/TrEMBL
    A6K2Y5, G3V8V4, Q3T1K1
    Conserved Domains (2) summary
    smart00724
    Location:131 → 332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71 → 128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  4. XM_006232887.5 → XP_006232949.1  ceramide synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006232949.1

    UniProtKB/TrEMBL
    A6K2Y5, G3V8V4, Q3T1K1
    Conserved Domains (2) summary
    smart00724
    Location:131 → 332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71 → 128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous