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Hist2h3c2 histone cluster 2 H3 family member C2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310678, updated on 10-Jul-2024

Summary

Official Symbol
Hist2h3c2provided by RGD
Official Full Name
histone cluster 2 H3 family member C2provided by RGD
Primary source
RGD:1306445
See related
EnsemblRapid:ENSRNOG00000070591 AllianceGenome:RGD:1306445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; chromatin binding activity; and protein heterodimerization activity. Predicted to be involved in nucleosome assembly. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H3C14 (H3 clustered histone 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 4783.0), Spleen (RPKM 3451.8) and 5 other tissues See more
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Genomic context

See Hist2h3c2 in Genome Data Viewer
Location:
2q34
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186526162..186526587)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183837296..183837721)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198390024..198418075)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 18 Neighboring gene H4 clustered histone 14 Neighboring gene H2B clustered histone 18 Neighboring gene uncharacterized LOC134485653 Neighboring gene Fc gamma receptor 1A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone cluster 2 H3 family member C2
Names
histone 2, H3c2
histone cluster 2 H3C family member 2
histone cluster 2, H3c2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107698.2NP_001101168.1  histone cluster 2 H3 family member C2

    See identical proteins and their annotated locations for NP_001101168.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6KLN8, D3ZJ08
    Related
    ENSRNOP00000109384.1, ENSRNOT00000123128.1
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186526162..186526587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)